PMID- 28717589
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 5
DP  - 2017
TI  - Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and 
      CDKN2B with type 2 diabetes mellitus in the Russian population.
PG  - e3414
LID - 10.7717/peerj.3414 [doi]
LID - e3414
AB  - BACKGROUND: The association of type 2 diabetes mellitus (T2DM) with the KCNJ11, 
      CDKAL1, SLC30A8, CDKN2B, and FTO genes in the Russian population has not been 
      well studied. In this study, we analysed the population frequencies of 
      polymorphic markers of these genes. METHODS: The study included 862 patients with 
      T2DM and 443 control subjects of Russian origin. All subjects were genotyped for 
      10 single nucleotide polymorphisms (SNPs) of the genes using real-time PCR 
      (TaqMan assays). HOMA-IR and HOMA-beta were used to measure insulin resistance and 
      beta-cell secretory function, respectively. RESULTS: The analysis of the frequency 
      distribution of polymorphic markers for genes KCNJ11, CDKAL1, SLC30A8 and CDKN2B 
      showed statistically significant associations with T2DM in the Russian 
      population. The association between the FTO gene and T2DM was not statistically 
      significant. The polymorphic markers rs5219 of the KCNJ11 gene, rs13266634 of the 
      SLC30A8 gene, rs10811661 of the CDKN2B gene and rs9465871, rs7756992 and 
      rs10946398 of the CDKAL1 gene showed a significant association with impaired 
      glucose metabolism or impaired beta-cell function. CONCLUSION: In the Russian 
      population, genes, which affect insulin synthesis and secretion in the beta-cells of 
      the pancreas, play a central role in the development of T2DM.
FAU - Nikitin, Aleksey G
AU  - Nikitin AG
AD  - Federal Research Clinical Center for Specialized Types of Health Care and Medical 
      Technologies of Federal Medical and Biology Agency, Moscow, Russian Federation.
FAU - Potapov, Viktor Y
AU  - Potapov VY
AD  - Clinic of New Medical Technologies "Archimedes", Moscow, Russian Federation.
FAU - Brovkina, Olga I
AU  - Brovkina OI
AD  - Federal Research Clinical Center for Specialized Types of Health Care and Medical 
      Technologies of Federal Medical and Biology Agency, Moscow, Russian Federation.
FAU - Koksharova, Ekaterina O
AU  - Koksharova EO
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
FAU - Khodyrev, Dmitry S
AU  - Khodyrev DS
AD  - Federal Research Clinical Center for Specialized Types of Health Care and Medical 
      Technologies of Federal Medical and Biology Agency, Moscow, Russian Federation.
FAU - Philippov, Yury I
AU  - Philippov YI
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
FAU - Michurova, Marina S
AU  - Michurova MS
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
FAU - Shamkhalova, Minara S
AU  - Shamkhalova MS
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
FAU - Vikulova, Olga K
AU  - Vikulova OK
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
AD  - I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
FAU - Smetanina, Svetlana A
AU  - Smetanina SA
AD  - Tyumen State Medical University, Tyumen, Russian Federation.
FAU - Suplotova, Lyudmila A
AU  - Suplotova LA
AD  - Tyumen State Medical University, Tyumen, Russian Federation.
FAU - Kononenko, Irina V
AU  - Kononenko IV
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
AD  - I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
FAU - Kalashnikov, Viktor Y
AU  - Kalashnikov VY
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
FAU - Smirnova, Olga M
AU  - Smirnova OM
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
AD  - I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
FAU - Mayorov, Alexander Y
AU  - Mayorov AY
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
AD  - I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
FAU - Nosikov, Valery V
AU  - Nosikov VV
AD  - State Research Institute of Genetics and Selection of Industrial Microorganisms, 
      Moscow, Russian Federation.
FAU - Averyanov, Alexander V
AU  - Averyanov AV
AD  - Federal Research Clinical Center for Specialized Types of Health Care and Medical 
      Technologies of Federal Medical and Biology Agency, Moscow, Russian Federation.
FAU - Shestakova, Marina V
AU  - Shestakova MV
AD  - Endocrinology Research Centre, Moscow, Russian Federation.
AD  - I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
LA  - eng
PT  - Journal Article
DEP - 20170713
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC5511504
OTO - NOTNLM
OT  - Genetic predisposition
OT  - Polymorphic marker
OT  - Type 2 diabetes mellitus
COIS- The authors declare there are no competing interests.
EDAT- 2017/07/19 06:00
MHDA- 2017/07/19 06:01
PMCR- 2017/07/13
CRDT- 2017/07/19 06:00
PHST- 2016/11/25 00:00 [received]
PHST- 2017/05/14 00:00 [accepted]
PHST- 2017/07/19 06:00 [entrez]
PHST- 2017/07/19 06:00 [pubmed]
PHST- 2017/07/19 06:01 [medline]
PHST- 2017/07/13 00:00 [pmc-release]
AID - 3414 [pii]
AID - 10.7717/peerj.3414 [doi]
PST - epublish
SO  - PeerJ. 2017 Jul 13;5:e3414. doi: 10.7717/peerj.3414. eCollection 2017.