PMID- 28719253
OWN - NLM
STAT- MEDLINE
DCOM- 20170823
LR  - 20181113
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 96
IP  - 6
DP  - 2017 Jun
TI  - Cost-Effectiveness Evaluation of a Novel Integrated Bite Case Management Program 
      for the Control of Human Rabies, Haiti 2014-2015.
PG  - 1307-1317
LID - 10.4269/ajtmh.16-0785 [doi]
AB  - AbstractHaiti has the highest burden of rabies in the Western hemisphere, with 
      130 estimated annual deaths. We present the cost-effectiveness evaluation of an 
      integrated bite case management program combining community bite investigations 
      and passive animal rabies surveillance, using a governmental perspective. The 
      Haiti Animal Rabies Surveillance Program (HARSP) was first implemented in three 
      communes of the West Department, Haiti. Our evaluation encompassed all 
      individuals exposed to rabies in the study area (N = 2,289) in 2014-2015. Costs 
      (2014 U.S. dollars) included diagnostic laboratory development, training of 
      surveillance officers, operational costs, and postexposure prophylaxis (PEP). We 
      used estimated deaths averted and years of life gained (YLG) from prevented 
      rabies as health outcomes. HARSP had higher overall costs (range: 
      $39,568-$80,290) than the no-bite-case-management (NBCM) scenario 
      ($15,988-$26,976), partly from an increased number of bite victims receiving PEP. 
      But HARSP had better health outcomes than NBCM, with estimated 11 additional 
      annual averted deaths in 2014 and nine in 2015, and 654 additional YLG in 2014 
      and 535 in 2015. Overall, HARSP was more cost-effective (US$ per death averted) 
      than NBCM (2014, HARSP: $2,891-$4,735, NBCM: $5,980-$8,453; 2015, HARSP: 
      $3,534-$7,171, NBCM: $7,298-$12,284). HARSP offers an effective human rabies 
      prevention solution for countries transitioning from reactive to preventive 
      strategies, such as comprehensive dog vaccination.
FAU - Undurraga, Eduardo A
AU  - Undurraga EA
AD  - Health Economics and Modeling Unit, Division of Preparedness and Emerging 
      Infections, National Center for Emerging and Zoonotic Infectious Diseases, 
      Centers for Disease Control and Prevention, Atlanta, Georgia.
FAU - Meltzer, Martin I
AU  - Meltzer MI
AD  - Health Economics and Modeling Unit, Division of Preparedness and Emerging 
      Infections, National Center for Emerging and Zoonotic Infectious Diseases, 
      Centers for Disease Control and Prevention, Atlanta, Georgia.
FAU - Tran, Cuc H
AU  - Tran CH
AD  - Poxvirus and Rabies Branch, Division of High Consequence Pathogens and Pathology, 
      National Center for Emerging and Zoonotic Infectious Diseases, Centers for 
      Disease Control and Prevention, Atlanta, Georgia.
FAU - Atkins, Charisma Y
AU  - Atkins CY
AD  - Health Economics and Modeling Unit, Division of Preparedness and Emerging 
      Infections, National Center for Emerging and Zoonotic Infectious Diseases, 
      Centers for Disease Control and Prevention, Atlanta, Georgia.
FAU - Etheart, Melissa D
AU  - Etheart MD
AD  - Haiti Country Office, Division of Global Health Protection, Center for Global 
      Health, Centers for Disease Control and Prevention, Port-au-Prince, Haiti.
FAU - Millien, Max F
AU  - Millien MF
AD  - Direction Production et Sante Animale, Protection Sanitaire, Ministere de 
      l'Agriculture, des Ressources Naturelles et du Developpement Rural, 
      Port-au-Prince, Haiti.
FAU - Adrien, Paul
AU  - Adrien P
AD  - Epidemiology, Laboratorie and Research, Ministere de la Sante Publique et de la 
      Population, Port-au-Prince, Haiti.
FAU - Wallace, Ryan M
AU  - Wallace RM
AD  - Poxvirus and Rabies Branch, Division of High Consequence Pathogens and Pathology, 
      National Center for Emerging and Zoonotic Infectious Diseases, Centers for 
      Disease Control and Prevention, Atlanta, Georgia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Rabies Vaccines)
SB  - IM
MH  - Animals
MH  - Bites and Stings/*economics/*epidemiology
MH  - Case Management/*economics
MH  - Cost-Benefit Analysis
MH  - Dog Diseases/epidemiology/prevention & control
MH  - Dogs
MH  - Haiti/epidemiology
MH  - Humans
MH  - Post-Exposure Prophylaxis/economics
MH  - Rabies/*economics/*epidemiology/*prevention & control
MH  - Rabies Vaccines/administration & dosage/economics
MH  - Vaccination
PMC - PMC5462564
EDAT- 2017/07/19 06:00
MHDA- 2017/08/24 06:00
PMCR- 2017/06/07
CRDT- 2017/07/19 06:00
PHST- 2017/07/19 06:00 [entrez]
PHST- 2017/07/19 06:00 [pubmed]
PHST- 2017/08/24 06:00 [medline]
PHST- 2017/06/07 00:00 [pmc-release]
AID - 10.4269/ajtmh.16-0785 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Jun;96(6):1307-1317. doi: 10.4269/ajtmh.16-0785.