PMID- 28719984
OWN - NLM
STAT- MEDLINE
DCOM- 20190815
LR  - 20190815
IS  - 2156-5899 (Electronic)
IS  - 2156-5872 (Print)
IS  - 2156-5899 (Linking)
VI  - 22
IP  - 4
DP  - 2017 Oct
TI  - Cytotoxic and Immunomodulatory Potential Activity of Physalis peruviana Fruit 
      Extracts on Cervical Cancer (HeLa) and Fibroblast (L929) Cells.
PG  - 777-787
LID - 10.1177/2156587217718751 [doi]
AB  - It was purposed to evaluate the biological potential of ethanol and isopropanol 
      crude extracts of ripe Physalis peruviana fruits. Cytotoxic and immunomodulatory 
      effects of the expression of interleukin-6, interleukin-8, and monocyte 
      chemoattractant protein-1 (MCP-1) were evaluated on human cervical cancer (HeLa) 
      and murine fibroblast (L929) cells. The composition was evaluated by 
      high-performance liquid chromatography diode-array detection and high-performance 
      liquid chromatography ultraviolet/visible detection. The presence of ursolic acid 
      and rosmarinic acid was found in both solvents. However, gallic acid, quercetin, 
      and epicatechin were higher in isopropanol extracts ( P < .05). The results 
      indicated a relationship among the total polyphenol content, antioxidant 
      activity, and cytotoxic activity that was dependent on the solvent used. 
      Isopropanol extracts presented a half-maximal inhibition concentration value 
      (IC(50)) of 60.48 +/- 3.8 mug/mL for HeLa cells and 66.62 +/- 2.67 mug/mL for L929 
      fibroblasts. The extracts reduced the release of interleukin-6, interleukin-8, 
      and MCP-1 in a dose-dependent manner. Extracts showed anticancer and 
      immunomodulatory potential for new complementary pharmaceutical products 
      development.
FAU - Mier-Giraldo, Helen
AU  - Mier-Giraldo H
AD  - 1 Universidad de La Sabana, Campus Puente del Comun, Cundinamarca, Colombia.
FAU - Diaz-Barrera, Luis Eduardo
AU  - Diaz-Barrera LE
AD  - 1 Universidad de La Sabana, Campus Puente del Comun, Cundinamarca, Colombia.
FAU - Delgado-Murcia, Lucy Gabriela
AU  - Delgado-Murcia LG
AD  - 2 Universidad Nacional de Colombia, Bogota, Colombia.
FAU - Valero-Valdivieso, Manuel Fernando
AU  - Valero-Valdivieso MF
AD  - 1 Universidad de La Sabana, Campus Puente del Comun, Cundinamarca, Colombia.
FAU - Caez-Ramirez, Gabriela
AU  - Caez-Ramirez G
AD  - 1 Universidad de La Sabana, Campus Puente del Comun, Cundinamarca, Colombia.
LA  - eng
PT  - Journal Article
DEP - 20170718
PL  - United States
TA  - J Evid Based Complementary Altern Med
JT  - Journal of evidence-based complementary & alternative medicine
JID - 101556804
RN  - 0 (Antioxidants)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytotoxins)
RN  - 0 (Immunologic Factors)
RN  - 0 (Interleukins)
RN  - 0 (Plant Extracts)
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Chemokine CCL2/immunology
MH  - Chromatography, High Pressure Liquid/methods
MH  - Cytotoxins/pharmacology
MH  - Female
MH  - Fibroblasts/immunology
MH  - Fruit
MH  - HeLa Cells
MH  - Humans
MH  - Immunologic Factors/pharmacology
MH  - Interleukins/immunology
MH  - Mice
MH  - *Physalis
MH  - *Plant Extracts/immunology/pharmacology
MH  - *Uterine Cervical Neoplasms/immunology/pathology/therapy
PMC - PMC5871299
OTO - NOTNLM
OT  - antioxidants
OT  - cytotoxicity
OT  - immunomodulatory
COIS- Declaration of Conflicting Interests: The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2017/07/20 06:00
MHDA- 2019/08/16 06:00
PMCR- 2017/07/18
CRDT- 2017/07/20 06:00
PHST- 2017/07/20 06:00 [pubmed]
PHST- 2019/08/16 06:00 [medline]
PHST- 2017/07/20 06:00 [entrez]
PHST- 2017/07/18 00:00 [pmc-release]
AID - 10.1177_2156587217718751 [pii]
AID - 10.1177/2156587217718751 [doi]
PST - ppublish
SO  - J Evid Based Complementary Altern Med. 2017 Oct;22(4):777-787. doi: 
      10.1177/2156587217718751. Epub 2017 Jul 18.