PMID- 28720048
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20180827
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 27
IP  - 2
DP  - 2018 Feb
TI  - Mesangial proliferative lupus nephritis with podocytopathy: a special entity of 
      lupus nephritis.
PG  - 303-311
LID - 10.1177/0961203317720526 [doi]
AB  - Mesangial proliferative lupus nephritis may coexist with podocytopathy, but its 
      clinical-morphological features, treatment response and outcomes have not been 
      compared with mesangial proliferative lupus nephritis without podocytopathy. In 
      this study, 125 biopsies of lupus nephritis patients showing mesangial 
      proliferation with mesangial immune deposits were collected and divided into 
      podocytopathy group (defined as podocyte foot process effacement (FPE) >50% with 
      nephrotic syndrome (NS)) and mesangial group (FPE </=50%, or FPE >50% without NS). 
      Mesangial proliferation and tubular- interstitial lesions were 
      semi-quantitatively analyzed. We found that the incidence of renal involvement as 
      the onset symptoms ( P < .001), nephrotic syndrome ( P < .001), acute kidney 
      injury ( P < .001), the degree of acute tubular- interstitial lesions ( 
      P < .001), and renal relapse (51.6% vs. 23.7%, P = .005) were significantly 
      higher in the podocytopathy group than in the mesangial group. In contrast, the 
      incidence of arthritis ( P < .001), fever ( P = .042), low serum C4 ( P = .008) 
      and hematuria ( P = .033) was significantly lower in the podocytopathy group than 
      in the mesangial group. No patients developed end stage renal disease or death 
      during a median follow-up of 64 (interquartile range (IQR) 37-103) months in the 
      podocytopathy group and 53 (IQR 30-83) months in the mesangial group. In 
      conclusion, mesangial proliferative lupus nephritis with and without 
      podocytopathy should be subdivided into two separate classes of lupus nephritis.
FAU - Wang, S F
AU  - Wang SF
AD  - National Clinical Research Center of Kidney Diseases, Jinling Hospital. Nanjing 
      University School of Medicine. Nanjing, China.
FAU - Chen, Y H
AU  - Chen YH
AD  - National Clinical Research Center of Kidney Diseases, Jinling Hospital. Nanjing 
      University School of Medicine. Nanjing, China.
FAU - Chen, D Q
AU  - Chen DQ
AD  - National Clinical Research Center of Kidney Diseases, Jinling Hospital. Nanjing 
      University School of Medicine. Nanjing, China.
FAU - Liu, Z Z
AU  - Liu ZZ
AD  - National Clinical Research Center of Kidney Diseases, Jinling Hospital. Nanjing 
      University School of Medicine. Nanjing, China.
FAU - Xu, F
AU  - Xu F
AD  - National Clinical Research Center of Kidney Diseases, Jinling Hospital. Nanjing 
      University School of Medicine. Nanjing, China.
FAU - Zeng, C H
AU  - Zeng CH
AD  - National Clinical Research Center of Kidney Diseases, Jinling Hospital. Nanjing 
      University School of Medicine. Nanjing, China.
FAU - Hu, W X
AU  - Hu WX
AD  - National Clinical Research Center of Kidney Diseases, Jinling Hospital. Nanjing 
      University School of Medicine. Nanjing, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170718
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
SB  - IM
MH  - Acute Kidney Injury/complications/pathology
MH  - Adult
MH  - Female
MH  - Hematuria/complications/pathology
MH  - Humans
MH  - Kidney/*pathology
MH  - Kidney Glomerulus/*pathology
MH  - Lupus Nephritis/*complications/epidemiology/metabolism/*pathology
MH  - Male
MH  - Mesangial Cells/*pathology
MH  - Nephrotic Syndrome/*complications/epidemiology/*pathology
MH  - Podocytes/*pathology
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Lupus nephritis
OT  - mesangial proliferation
OT  - podocytopathy
EDAT- 2017/07/20 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/07/20 06:00
PHST- 2017/07/20 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/07/20 06:00 [entrez]
AID - 10.1177/0961203317720526 [doi]
PST - ppublish
SO  - Lupus. 2018 Feb;27(2):303-311. doi: 10.1177/0961203317720526. Epub 2017 Jul 18.