PMID- 28721088
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 10
DP  - 2017
TI  - Forced exercise attenuates neuropathic pain in chronic constriction injury of 
      male rat: an investigation of oxidative stress and inflammation.
PG  - 1457-1466
LID - 10.2147/JPR.S135081 [doi]
AB  - BACKGROUND AND OBJECTIVE: Initial peripheral/central nerve injuries, such as 
      chronic constriction injury (CCI)/spinal cord injury, are often compounded by 
      secondary mechanisms, including inflammation and oxidative stress, which may lead 
      to chronic neuropathic pain characterized by hyperalgesia or allodynia. On the 
      other hand, exercise as a behavioral and non-pharmacological treatment has been 
      shown to alleviate chronic neuropathic pain. Therefore, this study was conducted 
      to examine whether or not exercise reduces neuropathic pain through modifying 
      oxidative stress and inflammation in chronic constriction injury of the sciatic 
      nerve. MATERIALS AND METHODS: Wistar male rats weighing 200+/-20 g were randomly 
      divided into five groups (normal, sham, CCI, pre-CCI exercise, and post-CCI 
      exercise group). Sciatic nerve of anesthetized rats was loosely ligated to induce 
      CCI, and they were then housed in separate cages. The rats ran on treadmill at a 
      moderate speed for 3 weeks. Mechanical allodynia and thermal hyperalgesia were 
      determined using von Frey filament and plantar test, respectively. Tumor necrosis 
      factor-alpha (TNF-alpha) assayed in the cerebrospinal fluid, malondialdehyde, and 
      total antioxidant capacity were measured in the serum using Western blot test, 
      thiobarbituric acid, and ferric reducing ability of plasma (FRAP), respectively. 
      RESULTS: The mechanical allodynia (P=0.024) and thermal hyperalgesia (P=0.002) in 
      the CCI group were higher than those in the sham group. Exercise after CCI 
      reduced (P=0.004) mechanical allodynia and thermal hyperalgesia (P=0.025) 
      compared with the CCI group. Moreover, the level of FRAP in the CCI group was 
      (P=0.001) lower than that in the sham group, and post-CCI exercise reversed FRAP 
      amount toward the control level (P=0.019). The amount of malondialdehyde did not 
      differ between groups. Level of TNF-alpha increased in the CCI group (P=0.0002) 
      compared with sham group and post-CCI exercise could reverse it toward the level 
      of control (P=0.005). CONCLUSION: Post CCI-exercise but not pre CCI-exercise 
      reduces CCI-induced neuropathic pain. One of the possible involved mechanisms is 
      increasing the total antioxidant capacity and reducing the amount of TNF-alpha.
FAU - Safakhah, Hossein Ali
AU  - Safakhah HA
AD  - Department of Physiology, Faculty of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
AD  - Research Center of Physiology, Faculty of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
FAU - Moradi Kor, Nasroallah
AU  - Moradi Kor N
AD  - Research Center of Physiology, Faculty of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
AD  - Student Research Committee, Faculty of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
FAU - Bazargani, Atiyeh
AU  - Bazargani A
AD  - Student Research Committee, Faculty of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
FAU - Bandegi, Ahmad Reza
AU  - Bandegi AR
AD  - Department of Biochemistry, Faculty of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
FAU - Gholami Pourbadie, Hamid
AU  - Gholami Pourbadie H
AD  - Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, 
      Iran.
FAU - Khoshkholgh-Sima, Baharak
AU  - Khoshkholgh-Sima B
AD  - Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, 
      Iran.
FAU - Ghanbari, Ali
AU  - Ghanbari A
AD  - Research Center of Physiology, Faculty of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170623
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC5499951
OTO - NOTNLM
OT  - CCI
OT  - TNF-alpha
OT  - neuropathic pain
OT  - oxidative stress
OT  - treadmill exercise
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/07/20 06:00
MHDA- 2017/07/20 06:01
PMCR- 2017/06/23
CRDT- 2017/07/20 06:00
PHST- 2017/07/20 06:00 [entrez]
PHST- 2017/07/20 06:00 [pubmed]
PHST- 2017/07/20 06:01 [medline]
PHST- 2017/06/23 00:00 [pmc-release]
AID - jpr-10-1457 [pii]
AID - 10.2147/JPR.S135081 [doi]
PST - epublish
SO  - J Pain Res. 2017 Jun 23;10:1457-1466. doi: 10.2147/JPR.S135081. eCollection 2017.