PMID- 28721157
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 13
IP  - 4
DP  - 2017 Jun
TI  - MicroRNAs and metabolic disorders - where are we heading?
PG  - 885-896
LID - 10.5114/aoms.2017.65229 [doi]
AB  - MicroRNAs (miRNAs, miRs) are short, non-coding molecules engaged in normal 
      functioning of eukaryotic cells, as negative regulators of gene expression. Since 
      the first discovery of miRNA in the early 1990s, hundreds of different miRNAs and 
      their targets have been identified. A growing number of studies have aimed to 
      search for microRNAs which have a key role in the regulation of insulin signaling 
      and metabolic homeostasis. Recent evidence indicates that dysregulation of miRNA 
      expression is involved in the development of various diseases, including type 2 
      diabetes mellitus (T2DM), obesity and cardiovascular diseases. This review 
      summarizes the biogenesis of miRNAs and their role in pancreatic beta cell biology, 
      insulin signaling and metabolism. We also discuss recent findings of miRNAs 
      associated with metabolic disorders and vascular diabetic complications, their 
      diagnosis and therapeutic value. The PubMed database and published reference 
      lists were searched for articles published between 1990 and 2016 using the 
      following keywords: miRNA, miRNA and pancreas; miRNA and insulin; miRNA and type 
      2 diabetes mellitus, miRNA and obesity, and miRNA and microvascular or 
      macrovascular diabetic complication. This review indicates that miRNA functioning 
      is significantly different in metabolic diseases than in the normal condition.
FAU - Sliwinska, Agnieszka
AU  - Sliwinska A
AD  - Department of Internal Diseases, Diabetology and Clinical Pharmacology, Medical 
      University of Lodz, Lodz, Poland.
FAU - Kasinska, Marta A
AU  - Kasinska MA
AD  - Department of Internal Diseases, Diabetology and Clinical Pharmacology, Medical 
      University of Lodz, Lodz, Poland.
FAU - Drzewoski, Jozef
AU  - Drzewoski J
AD  - Department of Internal Diseases, Diabetology and Clinical Pharmacology, Medical 
      University of Lodz, Lodz, Poland.
LA  - eng
PT  - Journal Article
DEP - 20170119
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC5507111
OTO - NOTNLM
OT  - insulin signaling
OT  - microRNA
OT  - obesity
OT  - type 2 diabetes
OT  - vascular diabetic complications
COIS- The authors declare no conflict of interest.
EDAT- 2017/07/20 06:00
MHDA- 2017/07/20 06:01
PMCR- 2017/06/01
CRDT- 2017/07/20 06:00
PHST- 2016/04/04 00:00 [received]
PHST- 2016/08/29 00:00 [accepted]
PHST- 2017/07/20 06:00 [entrez]
PHST- 2017/07/20 06:00 [pubmed]
PHST- 2017/07/20 06:01 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - 29138 [pii]
AID - 10.5114/aoms.2017.65229 [doi]
PST - ppublish
SO  - Arch Med Sci. 2017 Jun;13(4):885-896. doi: 10.5114/aoms.2017.65229. Epub 2017 Jan 
      19.