PMID- 28721548
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 34
IP  - 1
DP  - 2018 Jan
TI  - Left atrium passive ejection fraction is the most sensitive index of type 2 
      diabetes mellitus-related cardiac changes.
PG  - 141-151
LID - 10.1007/s10554-017-1213-0 [doi]
AB  - The aims of this study were to use cardiovascular magnetic resonance (CMR) cine 
      to assess left atrium (LA) and left ventricle (LV) function and structure in 
      normotensive type 2 diabetes mellitus (T2DM) patients and to identify the most 
      sensitive index of those T2DM-related cardiac changes. Fifty T2DM patients with 
      normotension (25 males, age 54.7 +/- 8.7 years, duration of diabetes: 7.5 +/- 5.1 
      years) and 35 controls (16 males, age: 52.2 +/- 13.2 years) were prospectively 
      enrolled. All patients were scanned using CMR four- and two-chamber long-axis 
      cine to assess LA and LV structure and function. Normotensive T2DM patients were 
      associated with decreased LA total ejection fraction (EF), passive EF and LV end 
      diastolic volume, normal LA active EF and LV myocardial mass and increased LV 
      mass/volume (M/V). LA total EF and passive EF correlated with body mass index, 
      duration of diabetes and M/V. To differentiate between diabetic patients and 
      healthy controls, area under the receiver operating characteristic (ROC) curve 
      (AUC) values were calculated to be 0.763, 0.706, 0.647 and 0.649 for LA passive 
      EF, total EF, LVEDV and M/V, respectively. The addition of LA total EF, LVEDV, 
      M/V and the combination thereof did not significantly improve AUC values in a 
      model containing LA passive EF. Normotensive T2DM patients were associated with 
      LA decreased total ejection fraction, decreased passive EF and LV concentric 
      remodeling. Among these indices, LA passive EF was the most sensitive to 
      T2DM-related LA function changes.
FAU - Shang, Yongning
AU  - Shang Y
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Zhang, Xiaochun
AU  - Zhang X
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China. zxcylxyr@163.com.
FAU - Leng, Weiling
AU  - Leng W
AD  - Department of Endocrinology, Southwest Hospital, Third Military Medical 
      University, Chongqing, China.
FAU - Lei, Xiaotian
AU  - Lei X
AD  - Department of Endocrinology, Southwest Hospital, Third Military Medical 
      University, Chongqing, China.
FAU - Chen, Liu
AU  - Chen L
AD  - Department of Endocrinology, Southwest Hospital, Third Military Medical 
      University, Chongqing, China.
FAU - Liang, Ziwen
AU  - Liang Z
AD  - Department of Endocrinology, Southwest Hospital, Third Military Medical 
      University, Chongqing, China. ziwenliang99@163.com.
FAU - Wang, Jian
AU  - Wang J
AUID- ORCID: 0000-0003-1210-0837
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University, 
      Chongqing, China. wangjian_811@yahoo.com.
LA  - eng
GR  - 81471647/National Natural Science Foundation of China/
GR  - 81571748/National Natural Science Foundation of China/
GR  - 18/SWH2016JSTSYB/
PT  - Journal Article
DEP - 20170718
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - *Atrial Function, Left
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis
MH  - Diabetic Cardiomyopathies/*diagnostic imaging/etiology/physiopathology
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Stroke Volume
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance cine
OT  - Diabetes mellitus
OT  - Left atrium
OT  - Left ventricle
EDAT- 2017/07/20 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/07/20 06:00
PHST- 2017/03/24 00:00 [received]
PHST- 2017/07/13 00:00 [accepted]
PHST- 2017/07/20 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/07/20 06:00 [entrez]
AID - 10.1007/s10554-017-1213-0 [pii]
AID - 10.1007/s10554-017-1213-0 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2018 Jan;34(1):141-151. doi: 10.1007/s10554-017-1213-0. 
      Epub 2017 Jul 18.