PMID- 28722106
OWN - NLM
STAT- MEDLINE
DCOM- 20180619
LR  - 20220409
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 47
IP  - 8
DP  - 2017 Aug
TI  - Anti-inflammatory effects of exercise: role in diabetes and cardiovascular 
      disease.
PG  - 600-611
LID - 10.1111/eci.12781 [doi]
AB  - BACKGROUND: Persistent inflammation is involved in the pathogenesis of chronic 
      diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular disease 
      (CVD). AIMS: The aim of this review was to provide the reader with an update of 
      the mechanisms whereby exercise-induced cytokines may impact cardiometabolic 
      diseases. RESULTS: Evidence exists that interleukin (IL)-1beta is involved in 
      pancreatic beta-cell damage, whereas TNF-alpha is a key molecule in peripheral insulin 
      resistance. In addition, TNF-alpha appears to be involved in the pathogenesis of 
      atherosclerosis and heart failure. A marked increase in IL-6 and IL-10 is 
      provoked by exercise and exerts direct anti-inflammatory effects by an inhibition 
      of TNF-alpha and by stimulating IL-1ra, thereby limiting IL-1beta signalling. Moreover, 
      muscle-derived IL-6 appears to have direct anti-inflammatory effects and serves 
      as a mechanism to improve glucose tolerance. In addition, indirect 
      anti-inflammatory effects of long-term exercise are mediated via improvements in 
      body composition. CONCLUSION: Physical activity represents a natural, strong 
      anti-inflammatory strategy with minor side effects and should be integrated in 
      the management of patients with cardiometabolic diseases.
CI  - (c) 2017 Stichting European Society for Clinical Investigation Journal Foundation.
FAU - Pedersen, Bente Klarlund
AU  - Pedersen BK
AUID- ORCID: 0000-0001-6508-6288
AD  - Centre of Inflammation and Metabolism/Centre for Physical Activity Research 
      (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170719
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Abdominal Fat/metabolism
MH  - Adaptation, Physiological/physiology
MH  - C-Reactive Protein/metabolism
MH  - Cytokines/metabolism
MH  - Diabetes Mellitus, Type 2/metabolism/*prevention & control
MH  - Exercise/*physiology
MH  - *Exercise Therapy
MH  - Heart Failure/metabolism/*prevention & control
MH  - Humans
MH  - Inflammation/physiopathology/prevention & control
MH  - Insulin-Secreting Cells/physiology
MH  - Interleukin-1beta/metabolism/physiology
MH  - Interleukin-6/physiology
MH  - Myocardial Ischemia/metabolism/*prevention & control
MH  - Tumor Necrosis Factor-alpha/physiology
MH  - Yin-Yang
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - cytokines
OT  - diabetes
OT  - exercise
OT  - heart failure
OT  - inflammation
EDAT- 2017/07/20 06:00
MHDA- 2018/06/20 06:00
CRDT- 2017/07/20 06:00
PHST- 2017/02/20 00:00 [received]
PHST- 2017/06/26 00:00 [accepted]
PHST- 2017/07/20 06:00 [pubmed]
PHST- 2018/06/20 06:00 [medline]
PHST- 2017/07/20 06:00 [entrez]
AID - 10.1111/eci.12781 [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2017 Aug;47(8):600-611. doi: 10.1111/eci.12781. Epub 2017 Jul 
      19.