PMID- 28724314
OWN - NLM
STAT- MEDLINE
DCOM- 20171018
LR  - 20181202
IS  - 1520-5762 (Electronic)
IS  - 0363-9045 (Linking)
VI  - 43
IP  - 12
DP  - 2017 Dec
TI  - Developing combination of artesunate with paclitaxel loaded into 
      poly-d,l-lactic-co-glycolic acid nanoparticle for systemic delivery to exhibit 
      synergic chemotherapeutic response.
PG  - 1952-1962
LID - 10.1080/03639045.2017.1357729 [doi]
AB  - OBJECTIVES: Paclitaxel (PTX) has been indicated for the treatment of a variety of 
      solid tumors, whereas artesunate (ART) has been reported to have the potential 
      for use in combination chemotherapy. In this study, the combination of ART and 
      PTX was prepared in nanoparticle to induce the synergic effect and improve 
      therapeutic efficiency in treatment of breast cancer. METHODS: Dual anticancer 
      agents (PTX and ART) were loaded into Poly-D,L-lactic-co-glycolic acid (PLGA) 
      nanoparticle (NP) by solvent evaporation technique from oil-in-water emulsion, 
      stabilized with Tween 80. Physicochemical properties of obtained nanoparticles 
      (PTX-ART-NPs) were characterized including particle size (Z), polydispersity 
      index (PDI), zeta potentials (ZP), encapsulation efficiency (EE), and in-vitro 
      drug release. Combination index (CI) was calculated to determine the synergic 
      effect of the combination and select the best ratio of ART and PTX. The final NPs 
      analyzed intracellular uptake, cytotoxicity assay, and apoptosis study. RESULTS: 
      The final NP had a small size (around 120 nm) with a narrow size distribution 
      (PDI <0.3). EE values for each drug were 87.8 +/- 1.1% and 99.5 +/- 0.1% for ART and 
      PTX, respectively, and drugs were released from NPs in a controlled release 
      pattern. All combinations of PTX and ART had CI values under 1, which confirmed 
      the synergic effects. Meanwhile, NP preparation increased cytotoxicity on three 
      breast cancer cell-lines comparable to free drugs. CONCLUSIONS: Combination of 
      ART- and PTX-loaded PLGA NP showed promising results for anticancer therapy, 
      especially for breast cancer treatment.
FAU - Tran, Bao Ngoc
AU  - Tran BN
AD  - a Department of Pharmaceutical Industry , Hanoi University of Pharmacy , Hanoi , 
      Vietnam.
FAU - Nguyen, Hanh Thuy
AU  - Nguyen HT
AD  - b College of Pharmacy , Yeungnam University , Gyeongsan , South Korea.
FAU - Kim, Jong Oh
AU  - Kim JO
AD  - b College of Pharmacy , Yeungnam University , Gyeongsan , South Korea.
FAU - Yong, Chul Soon
AU  - Yong CS
AD  - b College of Pharmacy , Yeungnam University , Gyeongsan , South Korea.
FAU - Nguyen, Chien Ngoc
AU  - Nguyen CN
AD  - a Department of Pharmaceutical Industry , Hanoi University of Pharmacy , Hanoi , 
      Vietnam.
AD  - c National Institute of Pharmaceutical Technology , Hanoi University of Pharmacy 
      , Hanoi , Vietnam.
LA  - eng
PT  - Journal Article
DEP - 20170803
PL  - England
TA  - Drug Dev Ind Pharm
JT  - Drug development and industrial pharmacy
JID - 7802620
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Artemisinins)
RN  - 0 (Drug Carriers)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 60W3249T9M (Artesunate)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Antineoplastic Agents/*administration & dosage/chemistry/pharmacology
MH  - Apoptosis/*drug effects
MH  - Artemisinins/*administration & dosage/chemistry/pharmacology
MH  - Artesunate
MH  - Breast Neoplasms/*drug therapy
MH  - Cell Line, Tumor
MH  - Drug Carriers/*chemistry
MH  - Humans
MH  - Lactic Acid/*chemistry
MH  - Nanoparticles/*chemistry
MH  - Paclitaxel/*administration & dosage/chemistry/pharmacology
MH  - Polyglycolic Acid/*chemistry
OTO - NOTNLM
OT  - Artesunate
OT  - PLGA
OT  - anti-cancer
OT  - combination therapy
OT  - nanoparticle
OT  - paclitaxel
EDAT- 2017/07/21 06:00
MHDA- 2017/10/19 06:00
CRDT- 2017/07/21 06:00
PHST- 2017/07/21 06:00 [pubmed]
PHST- 2017/10/19 06:00 [medline]
PHST- 2017/07/21 06:00 [entrez]
AID - 10.1080/03639045.2017.1357729 [doi]
PST - ppublish
SO  - Drug Dev Ind Pharm. 2017 Dec;43(12):1952-1962. doi: 
      10.1080/03639045.2017.1357729. Epub 2017 Aug 3.