PMID- 28725111
OWN - NLM
STAT- MEDLINE
DCOM- 20171227
LR  - 20181113
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 81
IP  - 3
DP  - 2017 Jul
TI  - Oxidative stress and food supplementation with antioxidants in therapy dogs.
PG  - 206-216
AB  - The objective of this study was to evaluate the ability of a long-term 
      antioxidant-supplemented diet to regulate the oxidative stress and general health 
      status of dogs involved in animal-assisted intervention (AAI) programs. Oxidative 
      stress is a consequence of the accumulation of reactive oxygen species (ROS). 
      Exercise-induced oxidative stress can increase muscle fatigue and fiber damage 
      and eventually leads to impairment of the immune system. A randomized, 
      placebo-controlled, crossover clinical evaluation was conducted with 11 healthy 
      therapy dogs: 6 females and 5 males of different breeds and with a mean age of 
      2.7 +/- 0.8 y (mean +/- SEM). The dogs were divided into 2 groups, 1 fed a high 
      quality commercial diet without antioxidants (CD) and the other a high quality 
      commercial diet supplemented with antioxidants (SD) for 18 wk. After the first 18 
      wk, metabolic parameters, reactive oxygen metabolite-derivatives (d-ROMs), and 
      biological antioxidant potential (BAP) levels were monitored and showed a 
      significant reduction of d-ROMs, triglycerides, and creatinine values in the SD 
      group (P < 0.05) and a significant increase in amylase values in the CD group (P 
      < 0.01). At the end of this period, groups were crossed over and fed for another 
      18 wk. A significant decrease in amylase and glutamate pyruvate transaminase 
      (GPT) values was observed in the CD and SD group, respectively (P < 0.05). In 
      conclusion, a controlled, balanced antioxidant diet may be a valid approach to 
      restoring good cell metabolism and neutralizing excess free radicals in therapy 
      dogs.
FAU - Sechi, Sara
AU  - Sechi S
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section 
      (Sechi, Fiore, Cocco) and Department of Agriculture, Livestock Sciences Section 
      (Dimauro, Nudda), University of Sassari, Sassari, Italy; Department of Diagnostic 
      Medicine, Clinical and Public Health, University of Modena and Reggio Emilia, 
      Modena, Italy (Chiavolelli).
FAU - Fiore, Filippo
AU  - Fiore F
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section 
      (Sechi, Fiore, Cocco) and Department of Agriculture, Livestock Sciences Section 
      (Dimauro, Nudda), University of Sassari, Sassari, Italy; Department of Diagnostic 
      Medicine, Clinical and Public Health, University of Modena and Reggio Emilia, 
      Modena, Italy (Chiavolelli).
FAU - Chiavolelli, Francesca
AU  - Chiavolelli F
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section 
      (Sechi, Fiore, Cocco) and Department of Agriculture, Livestock Sciences Section 
      (Dimauro, Nudda), University of Sassari, Sassari, Italy; Department of Diagnostic 
      Medicine, Clinical and Public Health, University of Modena and Reggio Emilia, 
      Modena, Italy (Chiavolelli).
FAU - Dimauro, Corrado
AU  - Dimauro C
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section 
      (Sechi, Fiore, Cocco) and Department of Agriculture, Livestock Sciences Section 
      (Dimauro, Nudda), University of Sassari, Sassari, Italy; Department of Diagnostic 
      Medicine, Clinical and Public Health, University of Modena and Reggio Emilia, 
      Modena, Italy (Chiavolelli).
FAU - Nudda, Anna
AU  - Nudda A
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section 
      (Sechi, Fiore, Cocco) and Department of Agriculture, Livestock Sciences Section 
      (Dimauro, Nudda), University of Sassari, Sassari, Italy; Department of Diagnostic 
      Medicine, Clinical and Public Health, University of Modena and Reggio Emilia, 
      Modena, Italy (Chiavolelli).
FAU - Cocco, Raffaella
AU  - Cocco R
AD  - Department of Veterinary Medicine, Pathology and Veterinary Clinic Section 
      (Sechi, Fiore, Cocco) and Department of Agriculture, Livestock Sciences Section 
      (Dimauro, Nudda), University of Sassari, Sassari, Italy; Department of Diagnostic 
      Medicine, Clinical and Public Health, University of Modena and Reggio Emilia, 
      Modena, Italy (Chiavolelli).
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (Antioxidants)
SB  - IM
MH  - Animal Feed/*analysis
MH  - Animals
MH  - Antioxidants/administration & dosage/*pharmacology
MH  - Cross-Over Studies
MH  - Diet/*veterinary
MH  - *Dietary Supplements
MH  - Dogs
MH  - Female
MH  - Male
MH  - Oxidative Stress/*drug effects
PMC - PMC5508397
COIS- The authors certify that there is no conflict of interest with any financial 
      organization regarding the material discussed in the manuscript.
EDAT- 2017/07/21 06:00
MHDA- 2017/12/28 06:00
PMCR- 2018/01/01
CRDT- 2017/07/21 06:00
PHST- 2016/11/07 00:00 [received]
PHST- 2017/01/04 00:00 [accepted]
PHST- 2017/07/21 06:00 [entrez]
PHST- 2017/07/21 06:00 [pubmed]
PHST- 2017/12/28 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - cjvr_03_206 [pii]
PST - ppublish
SO  - Can J Vet Res. 2017 Jul;81(3):206-216.