PMID- 28727804
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20181202
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 7
DP  - 2017
TI  - Effects of pre-surgical administration of prostaglandin analogs on the outcome of 
      trabeculectomy.
PG  - e0181550
LID - 10.1371/journal.pone.0181550 [doi]
LID - e0181550
AB  - For primary open angle glaucoma (POAG), laser treatment or surgery is used when 
      the target intraocular pressure (IOP) cannot be achieved by pharmacological 
      agents, such as prostaglandin (PG) analogs; these drugs also have varied effects. 
      We retrospectively reviewed the medical records of 74 POAG patients (74 eyes) 
      whose IOP was inadequately controlled by PG analogs (bimatoprost [13 eyes], 
      latanoprost [34 eyes], tafluprost [11 eyes], and travoprost [16 eyes]) and 
      underwent primary trabeculectomy. The proportion of patients with no recurrent 
      IOP elevation within 24 months post-trabeculectomy was significantly (P < 0.001) 
      lower in the bimatoprost group (31.3%) than in the latanoprost (83.2%), 
      tafluprost (45.5%), or travoprost groups (65.6%). Deepening of the upper eyelid 
      sulcus (DUES) was observed before trabeculectomy in 18 of 74 eyes (24.3%) treated 
      with bimatoprost (9 eyes; 50.0%), latanoprost (3 eyes; 16.7%), tafluprost (1 eye; 
      5.5%) and travoprost (5 eyes; 27.8%). The proportion of patients with no 
      recurrent IOP elevation up to 24 months post-trabeculectomy was significantly (P 
      < 0.0001) lower in the DUES(+) group (34.7%) than in the DUES(-) group (74.3%). 
      Multivariate stepwise logistic regression analysis, with no recurrent IOP 
      elevation used as dependent variable, and bimatoprost, latanoprost, travoprost, 
      tafluprost, beta-blocker, carbonic anhydrase inhibitor, brimonidine, gender, age, 
      preoperative IOP, mean deviation, duration of PG analog use before surgery, and 
      the number of ophthalmic solutions used as independent variables, identified only 
      bimatoprost as a significant independent factor (P = 0.0368). Thus, the outcome 
      of trabeculectomy varied depending on the PG analog used preoperatively, and 
      bimatoprost use was associated with a high risk of recurrent IOP elevation up to 
      2 years post-trabeculectomy. This may indicate that the incidence of DUES 
      differed with the PG analog used. Patients with glaucoma who are treated with 
      bimatoprost should be monitored for DUES, and when these patients undergo 
      trabeculectomy, the postoperative course of IOP should be followed carefully.
FAU - Miki, Takako
AU  - Miki T
AUID- ORCID: 0000-0002-8456-7121
AD  - Department of Ophthalmology, Okayama University Graduate School of Medicine, 
      Okayama, Japan.
FAU - Naito, Tomoko
AU  - Naito T
AD  - Department of Ophthalmology, Okayama University Graduate School of Medicine, 
      Okayama, Japan.
FAU - Fujiwara, Miyuki
AU  - Fujiwara M
AD  - Department of Ophthalmology, Okayama University Graduate School of Medicine, 
      Okayama, Japan.
FAU - Araki, Ryoichi
AU  - Araki R
AD  - Department of Ophthalmology, Okayama University Graduate School of Medicine, 
      Okayama, Japan.
FAU - Kiyoi, Rieko
AU  - Kiyoi R
AD  - Japanese Red Cross Okayama Hospital, Okayama, Japan.
FAU - Shiode, Yusuke
AU  - Shiode Y
AD  - Department of Ophthalmology, Okayama University Graduate School of Medicine, 
      Okayama, Japan.
FAU - Fujiwara, Atsushi
AU  - Fujiwara A
AD  - Department of Ophthalmology, Okayama University Graduate School of Medicine, 
      Okayama, Japan.
FAU - Morizane, Yuki
AU  - Morizane Y
AD  - Department of Ophthalmology, Okayama University Graduate School of Medicine, 
      Okayama, Japan.
FAU - Shiraga, Fumio
AU  - Shiraga F
AD  - Department of Ophthalmology, Okayama University Graduate School of Medicine, 
      Okayama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170720
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Prostaglandins F)
RN  - 0 (Prostaglandins F, Synthetic)
RN  - 0 (Prostaglandins, Synthetic)
RN  - 1O6WQ6T7G3 (tafluprost)
RN  - 6Z5B6HVF6O (Latanoprost)
RN  - QXS94885MZ (Bimatoprost)
RN  - WJ68R08KX9 (Travoprost)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Bimatoprost/administration & dosage
MH  - Female
MH  - Glaucoma/*drug therapy/physiopathology/*surgery
MH  - Humans
MH  - Intraocular Pressure/drug effects
MH  - Latanoprost
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Preoperative Care
MH  - Prostaglandins F/administration & dosage
MH  - Prostaglandins F, Synthetic/administration & dosage
MH  - Prostaglandins, Synthetic/*administration & dosage
MH  - Recurrence
MH  - Retrospective Studies
MH  - *Trabeculectomy
MH  - Travoprost/administration & dosage
MH  - Treatment Outcome
PMC - PMC5519176
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/07/21 06:00
MHDA- 2017/09/28 06:00
PMCR- 2017/07/20
CRDT- 2017/07/21 06:00
PHST- 2016/11/29 00:00 [received]
PHST- 2017/07/03 00:00 [accepted]
PHST- 2017/07/21 06:00 [entrez]
PHST- 2017/07/21 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2017/07/20 00:00 [pmc-release]
AID - PONE-D-16-47229 [pii]
AID - 10.1371/journal.pone.0181550 [doi]
PST - epublish
SO  - PLoS One. 2017 Jul 20;12(7):e0181550. doi: 10.1371/journal.pone.0181550. 
      eCollection 2017.