PMID- 2872873
OWN - NLM
STAT- MEDLINE
DCOM- 19860722
LR  - 20041117
IS  - 0003-9985 (Print)
IS  - 0003-9985 (Linking)
VI  - 110
IP  - 7
DP  - 1986 Jul
TI  - Microscopic peliosis of pancreatic islets in a woman with MEN-1 syndrome.
PG  - 607-10
AB  - We report herein a case of histologically identified peliosis of pancreatic 
      islets in the surgically removed portion of the pancreas of a 30-year-old woman 
      with multiple endocrine neoplasm, type 1 (MEN-1) syndrome. In addition to 
      microscopic peliosis, the pancreas contained multiple endocrine tumors producing 
      insulin, glucagon, somatostatin, and growth hormone-releasing factor and showed 
      evidence of widespread nesidioblastosis. It is uncertain whether peliosis of 
      pancreatic islets and MEN-1 syndrome were coincidental or whether the two 
      diseases were causally related. Since hormonal factors can result in hepatic 
      peliosis, it is tempting to speculate that the endocrine imbalance secondary to 
      MEN-1 syndrome might have played a role in the genesis of peliosis in this case. 
      Although no direct proof of vascular damage was encountered, it is conceivable 
      that escape of red blood cells from the circulation and their accumulation in 
      tissue spaces was due to abnormal islet blood flow and increased capillary 
      permeability.
FAU - Kovacs, K
AU  - Kovacs K
FAU - Horvath, E
AU  - Horvath E
FAU - Asa, S L
AU  - Asa SL
FAU - Murray, D
AU  - Murray D
FAU - Singer, W
AU  - Singer W
FAU - Reddy, S S
AU  - Reddy SS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
SB  - IM
MH  - Adult
MH  - Capillary Permeability
MH  - Erythrocytes/ultrastructure
MH  - Female
MH  - Humans
MH  - Islets of Langerhans/*pathology/physiopathology/ultrastructure
MH  - Multiple Endocrine Neoplasia/*pathology/physiopathology/ultrastructure
MH  - Pancreatic Neoplasms/*pathology/physiopathology/ultrastructure
MH  - Purpura/*pathology/physiopathology
EDAT- 1986/07/01 00:00
MHDA- 1986/07/01 00:01
CRDT- 1986/07/01 00:00
PHST- 1986/07/01 00:00 [pubmed]
PHST- 1986/07/01 00:01 [medline]
PHST- 1986/07/01 00:00 [entrez]
PST - ppublish
SO  - Arch Pathol Lab Med. 1986 Jul;110(7):607-10.