PMID- 28728880
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20180525
IS  - 1567-7257 (Electronic)
IS  - 1567-1348 (Linking)
VI  - 54
DP  - 2017 Oct
TI  - Genetic adaptation to historical pathogen burdens.
PG  - 299-307
LID - S1567-1348(17)30246-0 [pii]
LID - 10.1016/j.meegid.2017.07.017 [doi]
AB  - Historical pathogen burdens are examined as possible triggers for genetic 
      adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 
      (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen 
      (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. 
      Results are robust to controlling for the physical and historical environment 
      humans faced, and to endogeneity of the historical pathogen burden measure. The 
      present study represents a proof-of-concept which may pave the way to the 
      analysis of future aggregate measures coming from whole-genome 
      sequencing/genotyping data.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Fedderke, Johannes W
AU  - Fedderke JW
AD  - Pennsylvania State University, School of International Affairs, State College, 
      PA, USA. Electronic address: jwf15@psu.edu.
FAU - Klitgaard, Robert E
AU  - Klitgaard RE
AD  - Claremont Graduate University, School of Social Sciences, Policy and Evaluation, 
      Claremont, CA, USA.
FAU - Napolioni, Valerio
AU  - Napolioni V
AD  - Stanford University, School of Medicine, Palo Alto, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170717
PL  - Netherlands
TA  - Infect Genet Evol
JT  - Infection, genetics and evolution : journal of molecular epidemiology and 
      evolutionary genetics in infectious diseases
JID - 101084138
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adaptation, Biological/*genetics
MH  - Algorithms
MH  - Alleles
MH  - *Biological Evolution
MH  - Gene Frequency
MH  - Genetic Markers
MH  - Genetic Variation
MH  - Host-Pathogen Interactions/*genetics
MH  - Humans
MH  - Models, Theoretical
OTO - NOTNLM
OT  - Genetic adaptation
OT  - Geography
OT  - Historical pathogen burdens
OT  - Paleohistorical markers
EDAT- 2017/07/22 06:00
MHDA- 2018/05/22 06:00
CRDT- 2017/07/22 06:00
PHST- 2017/03/29 00:00 [received]
PHST- 2017/07/07 00:00 [revised]
PHST- 2017/07/13 00:00 [accepted]
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2017/07/22 06:00 [entrez]
AID - S1567-1348(17)30246-0 [pii]
AID - 10.1016/j.meegid.2017.07.017 [doi]
PST - ppublish
SO  - Infect Genet Evol. 2017 Oct;54:299-307. doi: 10.1016/j.meegid.2017.07.017. Epub 
      2017 Jul 17.