PMID- 28729150
OWN - NLM
STAT- MEDLINE
DCOM- 20180627
LR  - 20190610
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Print)
IS  - 1083-8791 (Linking)
VI  - 23
IP  - 11
DP  - 2017 Nov
TI  - Dendritic Cell Recovery Impacts Outcomes after Umbilical Cord Blood and Sibling 
      Donor Transplantation for Hematologic Malignancies.
PG  - 1925-1931
LID - S1083-8791(17)30578-5 [pii]
LID - 10.1016/j.bbmt.2017.07.008 [doi]
AB  - Dendritic cells (DCs) orchestrate immune responses after allogeneic hematopoietic 
      cell transplantation (HCT). We studied the association of donor myeloid DCs 
      (mDCs) and plasmacytoid DCs (pDCs) recovery in the landmark analysis of umbilical 
      cord blood (UCB) and matched related donor (RD) HCT. Eighty patients (42 UCB and 
      38 RD recipients) with a day 100 blood sample were included in the analysis. 
      Median age was 51 years (range, 20 to 71). Most patients had acute leukemia (50%) 
      or lymphoma (23%) and received reduced-intensity conditioning (75%). After 
      transplantation, UCB recipients had higher DC counts than RD recipients reaching 
      normal levels at day 100 after transplantation (UCB median 4.7 cells/microL versus RD 
      median 1.7 cells/microL). UCB recipients with high day 100 pDCs levels (>/= median) had 
      2-fold lower risk of relapse compared with those with pDC(low) (14% versus 28%, 
      P = .29) and a trend to improved 1-year survival in multivariate analysis with 
      hazard ratio of .22 (95% confidence interval, .04 to 1.05; P = .057). 
      Cytomegalovirus (CMV) reactivation had adverse impact on DC reconstitution at day 
      100 in both UCB and RD groups and almost exclusively affected the mDC subset (CMV 
      reactivation: mDC 3.2 cells/microL versus no CMV reactivation: 7.8 cells/microL; 
      P = .004). Collectively, these data suggest that high levels of circulating pDCs 
      at day 100 after UCB transplantation confer a survival advantage at 1 year.
CI  - Copyright (c) 2017 The American Society for Blood and Marrow Transplantation. 
      Published by Elsevier Inc. All rights reserved.
FAU - Touma, Waseem
AU  - Touma W
AD  - Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, 
      Minnesota.
FAU - Brunstein, Claudio G
AU  - Brunstein CG
AD  - Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, 
      Minnesota.
FAU - Cao, Qing
AU  - Cao Q
AD  - Biostatistics and Informatics Core, Masonic Cancer Center, University of 
      Minnesota, Minneapolis, Minnesota.
FAU - Miller, Jeffrey S
AU  - Miller JS
AD  - Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, 
      Minnesota.
FAU - Curtsinger, Julie
AU  - Curtsinger J
AD  - Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, 
      Minnesota.
FAU - Verneris, Michael R
AU  - Verneris MR
AD  - Colorado School of Medicine, Children's Hospital Colorado, Aurora, Colorado.
FAU - Bachanova, Veronika
AU  - Bachanova V
AD  - Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, 
      Minnesota. Electronic address: bach0173@umn.edu.
LA  - eng
GR  - P01 CA065493/CA/NCI NIH HHS/United States
GR  - P30 CA077598/CA/NCI NIH HHS/United States
GR  - UL1 TR000114/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20170717
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cord Blood Stem Cell Transplantation/*methods
MH  - Dendritic Cells/*metabolism
MH  - Female
MH  - Hematologic Neoplasms/mortality/pathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Siblings
MH  - Survival Analysis
MH  - Tissue Donors
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC6083873
MID - NIHMS920207
OTO - NOTNLM
OT  - Dendritic cells
OT  - Related donor transplantation
OT  - Umbilical cord blood transplantation
COIS- The authors have no conflicts of interest to report.
EDAT- 2017/07/22 06:00
MHDA- 2018/06/28 06:00
PMCR- 2018/08/09
CRDT- 2017/07/22 06:00
PHST- 2017/03/19 00:00 [received]
PHST- 2017/07/12 00:00 [accepted]
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2018/06/28 06:00 [medline]
PHST- 2017/07/22 06:00 [entrez]
PHST- 2018/08/09 00:00 [pmc-release]
AID - S1083-8791(17)30578-5 [pii]
AID - 10.1016/j.bbmt.2017.07.008 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2017 Nov;23(11):1925-1931. doi: 
      10.1016/j.bbmt.2017.07.008. Epub 2017 Jul 17.