PMID- 28730184
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2468-0249 (Print)
IS  - 2468-0249 (Electronic)
IS  - 2468-0249 (Linking)
VI  - 2
IP  - 4
DP  - 2017 Jul
TI  - Associations between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes.
PG  - 749-758
LID - 10.1016/j.ekir.2017.03.007 [doi]
AB  - INTRODUCTION: Existing methods to predict recipient allograft function during 
      deceased-donor kidney procurement are imprecise. Understanding the potential 
      renal reparative role for monocyte chemoattractant protein-1 (MCP-1), a cytokine 
      involved in macrophage recruitment after injury, might help predict allograft 
      outcomes. METHODS: We conducted a sub-study of the multicenter prospective 
      Deceased Donor Study cohort, which evaluated deceased kidney donors from five 
      organ procurement organizations from May 2010 to December 2013. We measured urine 
      MCP-1 (uMCP-1) concentrations from donor samples collected at nephrectomy to 
      determine associations with donor acute kidney injury (AKI), recipient delayed 
      graft function (DGF), 6-month estimated GFR (eGFR), and graft failure. We also 
      assessed perfusate MCP-1 concentrations from pumped kidneys for associations with 
      DGF and 6-month eGFR. RESULTS: AKI occurred in 111 (9%) donors. Median 
      (interquartile range) uMCP-1 concentration was higher in donors with AKI compared 
      to donors without AKI (1.35 [0.41-3.93] ng/ml vs. 0.32 [0.11-0.80] ng/ml, 
      p<0.001). DGF occurred in 756 (31%) recipients, but uMCP-1 was not independently 
      associated with DGF. Higher donor uMCP-1 concentrations were independently 
      associated with higher 6-month eGFR in those without DGF [0.77 (0.10, 1.45) 
      ml/min/1.73m(2) per doubling of uMCP1]. However, there were no independent 
      associations between uMCP-1 and graft failure over a median follow-up of about 2 
      years. Lastly, perfusate MCP-1 concentrations significantly increased during pump 
      perfusion but were not associated with DGF or 6-month eGFR. CONCLUSION: Donor 
      uMCP-1 concentrations were modestly associated with higher recipient 6-month eGFR 
      in those without DGF. However, the results suggest that donor uMCP-1 has minimal 
      clinical utility given no associations with graft failure.
FAU - Mansour, S G
AU  - Mansour SG
AD  - Program of Applied Translational Research, Department of Medicine, Yale 
      University School of Medicine, New Haven, CT.
AD  - Section of Nephrology, Yale University School of Medicine, New Haven, CT.
FAU - Puthumana, J
AU  - Puthumana J
AD  - Program of Applied Translational Research, Department of Medicine, Yale 
      University School of Medicine, New Haven, CT.
FAU - Reese, P P
AU  - Reese PP
AD  - Renal-Electrolyte and Hypertension Division, Perelman School of Medicine at the 
      University of Pennsylvania, Philadelphia, PA.
FAU - Hall, I E
AU  - Hall IE
AD  - Division of Nephrology, Hypertension and Renal Transplantation, Department of 
      Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT.
FAU - Doshi, M D
AU  - Doshi MD
AD  - Wayne State University, Detroit, MI.
FAU - Weng, F L
AU  - Weng FL
AD  - Saint Barnabas Medical Center, Livingston, NJ.
FAU - Schroppel, B
AU  - Schroppel B
AD  - Section of Nephrology, University Hospital, Ulm, Germany.
FAU - Thiessen-Philbrook, H
AU  - Thiessen-Philbrook H
AD  - Program of Applied Translational Research, Department of Medicine, Yale 
      University School of Medicine, New Haven, CT.
FAU - Bimali, M
AU  - Bimali M
AD  - Program of Applied Translational Research, Department of Medicine, Yale 
      University School of Medicine, New Haven, CT.
FAU - Parikh, C R
AU  - Parikh CR
AD  - Program of Applied Translational Research, Department of Medicine, Yale 
      University School of Medicine, New Haven, CT.
AD  - Section of Nephrology, Yale University School of Medicine, New Haven, CT.
AD  - Veterans Affairs Connecticut Healthcare System, New Haven, CT.
LA  - eng
GR  - R01 DK093770/DK/NIDDK NIH HHS/United States
GR  - P30 DK079310/DK/NIDDK NIH HHS/United States
GR  - T32 DK007276/DK/NIDDK NIH HHS/United States
GR  - U01 HL108638/HL/NHLBI NIH HHS/United States
GR  - P30 DK090744/DK/NIDDK NIH HHS/United States
GR  - K24 DK090203/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20170331
PL  - United States
TA  - Kidney Int Rep
JT  - Kidney international reports
JID - 101684752
PMC - PMC5512592
MID - NIHMS878526
OTO - NOTNLM
OT  - 6-month eGFR
OT  - AKI
OT  - DGF
OT  - Graft failure
OT  - MCP-1
OT  - deceased donors
OT  - recipient outcomes
EDAT- 2017/07/22 06:00
MHDA- 2017/07/22 06:01
PMCR- 2017/03/31
CRDT- 2017/07/22 06:00
PHST- 2017/07/22 06:00 [entrez]
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2017/07/22 06:01 [medline]
PHST- 2017/03/31 00:00 [pmc-release]
AID - S2468-0249(17)30061-X [pii]
AID - 10.1016/j.ekir.2017.03.007 [doi]
PST - ppublish
SO  - Kidney Int Rep. 2017 Jul;2(4):749-758. doi: 10.1016/j.ekir.2017.03.007. Epub 2017 
      Mar 31.