PMID- 28730238
OWN - NLM
STAT- MEDLINE
DCOM- 20180420
LR  - 20211204
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 58
IP  - 2
DP  - 2017
TI  - Altered expression of mTOR and autophagy in term normal human placentas.
PG  - 517-526
AB  - Mammalian target of rapamycin (mTOR) and autophagy have been implied in 
      trophoblast cells proliferation and invasion. This study investigated whether 
      mTOR and autophagy were involved in placental development and fetal programming. 
      A total of 90 term normal placentas (37-42 gestational weeks) were collected from 
      women who underwent elective cesarean section, with large for gestational age 
      (LGA), fetal growth restriction (FGR), and appropriate for gestational age (AGA) 
      infants (n=30, respectively). Capillary volume density within peripheral villi 
      significantly decreased in the FGR placentas compared with the AGA group 
      (p<0.01). Autophagic vacuoles were more prominent in the FGR placentas than in 
      the AGA pregnancies (p<0.001). LC3B-II and Beclin1 in placentas of FGR were 
      increased by 99% and 83%, respectively, while p62 was descended by 39% (p<0.001), 
      compared with that in the AGA group. Whereas, there was no significant 
      differences in these autophagy-related proteins between the LGA and AGA 
      pregnancies. Compared to the AGA pregnancies, placental mTOR was reduced by 30% 
      in the FGR group and raised by 26% in the LGA group (p<0.05). Pearson's 
      correlation analysis showed a significantly inverse correlation between mTOR 
      level and LC3B-II expression (r=-0.456, p<0.01), as well as between mTOR and 
      Beclin1 expression in term human placentas (r=-0.468, p<0.01). These results 
      demonstrate that altered expression of mTOR and autophagy may be associated with 
      the development of placentas and pathophysiology of FGR, and that there may be a 
      reciprocal regulation between mTOR and autophagy in human placentas.
FAU - Zhang, Qiu Xia
AU  - Zhang QX
AD  - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical 
      University, Shenyang, China; songww1970@163.com.
FAU - Na, Quan
AU  - Na Q
FAU - Song, Weiwei
AU  - Song W
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Autophagy
MH  - Female
MH  - Humans
MH  - Placenta/*metabolism/pathology
MH  - Pregnancy
MH  - TOR Serine-Threonine Kinases/*metabolism
EDAT- 2017/07/22 06:00
MHDA- 2018/04/21 06:00
CRDT- 2017/07/22 06:00
PHST- 2017/07/22 06:00 [entrez]
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2018/04/21 06:00 [medline]
AID - 580217517526 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2017;58(2):517-526.