PMID- 28730779
OWN - NLM
STAT- MEDLINE
DCOM- 20190712
LR  - 20190712
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 22
IP  - 3
DP  - 2017 May-Jun
TI  - A comparative study on postoperative mortality prediction of SFLI scoring system 
      and Child-Pugh classification in patients with hepatocellular carcinoma.
PG  - 709-713
AB  - PURPOSE: In our previous study, we have established the clinical significance of 
      the SFLI (scoring formula of liver injury), the purpose of this study was to 
      compare the SFLI system and the Child-Pugh grading system in the prediction of 
      postoperative mortality in patients with hepatocellular carcinoma (HCC). METHODS: 
      114 patients with HCC who underwent surgical treatment were enrolled. According 
      to the requirement of the indicators for the Child-Pugh classification, various 
      indices (including albumin [ALB], total bilirubin [TBIL], prothrombin time [PT], 
      ascites, and hepatic encephalopathy) were considered in these patients before 
      surgery, and then Child-Pugh grading was performed. Similarly, the serum 
      biochemical markers including ALB, pre-albumin (PA), TBIL, serum creatining 
      (SCR), international normalized ratio (INR), alanine transminase (ALT), aspartate 
      transaminase (AST), gamma-glutamyl transpeptidase (ggr;-GT), alkaline phosphatase 
      (ALP), PT, activated partial thromboplastin time (APTT), and thrombine time (TT) 
      were collected before surgery for SFLI analysis. The predicted postoperative 
      mortality rates of these two scoring models and their diagnostic efficacy were 
      analyzed and compared. RESULTS: According to the Child-Pugh grading system, in 
      level A, B and C were 75, 35, and 4 cases respectively, and the corresponding 
      mortality rates were 1.3% (1/75), 17.1% (6/35) and 75% (3/4). Meanwhile, 
      according to the SLFI classification, the number of patients in the grade I, I+, 
      II, and III were 36, 29, 28, and 21, respectively, and the corresponding 
      mortality rates were 0, 0, 14.3% (4/28), and 28.6% (6/21), respectively. The 
      patient mortality rate increased significantly with increasing grading (p<0.01). 
      These two classification methods were further compared using ROC analysis, in 
      which the area under the curve (AUC) for the Child-Pugh method was 10.2% with a 
      95% confidence interval (95% CI) 17-18, and the AUC of SFLI was 88.2% with a 95% 
      CI 80-96. CONCLUSION: The SFLI scoring system is very useful in the assessment of 
      liver function and postoperative mortality, and its grading standard is much 
      better than the traditional Child-Pugh classification in many aspects.
FAU - Zheng, Jun
AU  - Zheng J
AD  - Institute of Hepatopancreatobiliary Surgery, Department of General Surgery, the 
      First College of Clinical Medical Science, China Three Gorges University, Yichang 
      443002, China.
FAU - Xing, Rong-Chun
AU  - Xing RC
FAU - Zheng, Wei-Hong
AU  - Zheng WH
FAU - Liu, Wei
AU  - Liu W
FAU - Yao, Ru-Cheng
AU  - Yao RC
FAU - Li, Xiao-Song
AU  - Li XS
FAU - Du, Jian-Ping
AU  - Du JP
FAU - Li, Lin
AU  - Li L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Carcinoma, Hepatocellular/mortality/pathology/physiopathology/*surgery
MH  - Humans
MH  - Liver/physiopathology
MH  - Liver Neoplasms/mortality/pathology/physiopathology/*surgery
MH  - Neoplasm Grading
MH  - Serum Albumin/analysis
MH  - *Severity of Illness Index
EDAT- 2017/07/22 06:00
MHDA- 2019/07/13 06:00
CRDT- 2017/07/22 06:00
PHST- 2017/07/22 06:00 [entrez]
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2019/07/13 06:00 [medline]
PST - ppublish
SO  - J BUON. 2017 May-Jun;22(3):709-713.