PMID- 28731588
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20221207
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 90
IP  - 4
DP  - 2017 Oct
TI  - Human leukocyte antigen distribution and genomic ancestry in Brazilian patients 
      with sickle cell disease.
PG  - 211-218
LID - 10.1111/tan.13102 [doi]
AB  - Hematopoietic stem-cell transplantation (HSCT) is currently the only established 
      curative treatment for sickle cell disease (SCD), but is limited by donor 
      availability. Ethnicity is thought to have an impact on the complications 
      experienced by patients that undergo HSCT and on the likelihood of identifying an 
      human leukocyte antigen (HLA) matched donor. In the present study, we 
      investigated the genomic ancestry and the distribution of HLA allele groups in 
      Brazilian patients with SCD, compared these HLA profiles to worldwide populations 
      and evaluate the availability of HLA-matched donors. A broad intercontinental 
      admixture of patients with SCD was observed, with African ancestry ranging from 
      6.7% to 93.4%. In a dendrogram based on HLA frequencies, Brazilian patients with 
      SCD were included in a branch containing only populations with a significant 
      African component. Among the 126 patients evaluated, 10 (8%) found a HLA-matched 
      unrelated donor in a database of 18 134 donors. Self-reported white, brown and 
      black matched donors were identified, and no significant difference in the 
      percentage of compatible donors was observed between these ethnic groups. Our 
      results show that Brazilian patients with SCD are very admixed, indicating that 
      this group is a promising target for admixture mapping of genes involved in 
      complications after HSCT. Additional studies may help to clarify the impact of 
      the genetic diversity and admixture of these patients on the donor availability.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - da Silva-Malta, M C F
AU  - da Silva-Malta MCF
AUID- ORCID: 0000-0002-5284-6425
AD  - Fundacao Centro de Hematologia e Hemoterapia de Minas Gerais - Hemominas, Belo 
      Horizonte, Brazil.
FAU - Rodrigues, P S
AU  - Rodrigues PS
AD  - Fundacao Centro de Hematologia e Hemoterapia de Minas Gerais - Hemominas, Belo 
      Horizonte, Brazil.
FAU - Zuccherato, L W
AU  - Zuccherato LW
AD  - Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade 
      Federal de Minas Gerais, Belo Horizonte, Brazil.
FAU - de Souza, F C B
AU  - de Souza FCB
AD  - Fundacao Centro de Hematologia e Hemoterapia de Minas Gerais - Hemominas, Belo 
      Horizonte, Brazil.
FAU - Domingues, E M F L
AU  - Domingues EMFL
AD  - Fundacao Centro de Hematologia e Hemoterapia de Minas Gerais - Hemominas, Belo 
      Horizonte, Brazil.
FAU - Souza, V R
AU  - Souza VR
AD  - Fundacao Centro de Hematologia e Hemoterapia de Minas Gerais - Hemominas, Belo 
      Horizonte, Brazil.
FAU - Tarazona-Santos, E
AU  - Tarazona-Santos E
AD  - Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade 
      Federal de Minas Gerais, Belo Horizonte, Brazil.
FAU - Martins, M L
AU  - Martins ML
AD  - Fundacao Centro de Hematologia e Hemoterapia de Minas Gerais - Hemominas, Belo 
      Horizonte, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170811
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Anemia, Sickle Cell/*ethnology/*genetics/immunology/therapy
MH  - Asian People/genetics
MH  - Black People/genetics
MH  - Brazil
MH  - Donor Selection
MH  - Female
MH  - Gene Expression
MH  - *Gene Frequency
MH  - Genetic Variation
MH  - HLA Antigens/classification/*genetics/immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Phylogeny
MH  - Phylogeography
MH  - Transplantation, Homologous
MH  - *Unrelated Donors
MH  - White People/genetics
OTO - NOTNLM
OT  - HLA
OT  - ancestry
OT  - hematopoietic stem-cell transplantation
OT  - sickle cell disease
EDAT- 2017/07/22 06:00
MHDA- 2018/05/16 06:00
CRDT- 2017/07/22 06:00
PHST- 2017/01/12 00:00 [received]
PHST- 2017/06/13 00:00 [revised]
PHST- 2017/07/18 00:00 [accepted]
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2017/07/22 06:00 [entrez]
AID - 10.1111/tan.13102 [doi]
PST - ppublish
SO  - HLA. 2017 Oct;90(4):211-218. doi: 10.1111/tan.13102. Epub 2017 Aug 11.