PMID- 28731890
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20180622
IS  - 1533-4023 (Electronic)
IS  - 0160-2446 (Linking)
VI  - 70
IP  - 5
DP  - 2017 Nov
TI  - Metformin Exposure During Pregnancy and Lactation Did Not Cause Vascular 
      Reactivity Alteration in Adult Male Offsprings.
PG  - 300-304
LID - 10.1097/FJC.0000000000000520 [doi]
AB  - Metformin has been used for the treatment of some metabolic diseases during 
      gestation and the beneficial effects of metformin to the vascular system have 
      been described in diabetic and obese animal models. Nevertheless, the long-term 
      consequences to the vascular system of offsprings maternally exposed to metformin 
      have not yet been characterized. Therefore, we want to test the hypothesis that 
      gestational and lactational exposure to metformin would be safe for the vascular 
      reactivity of male adult offsprings. Wistar female rats were treated with 
      metformin 293 mg.kg.d, by gavage, from gestational day (GD) 0 to GD 21 (METG) or 
      GD 0 until postnatal day 21 (METGL). Control dams received water by gavage in the 
      same periods (CTRG and CTRGL). In male offsprings (75 days), the aortic 
      reactivity to phenylephrine, acetylcholine, and sodium nitroprusside in the 
      presence or absence of endothelium were evaluated. The results demonstrated that 
      aortic contraction and relaxation were similar between groups. These data showed 
      that metformin exposure during pregnancy and lactation did not interfere with 
      aortic reactivity, suggesting that metformin exposure during gestational and 
      lactation are safe for the offsprings' vascular system.
FAU - Novi, Daniella R B S
AU  - Novi DRBS
AD  - Department of Physiological Sciences, Biological Sciences Center, State 
      University of Londrina, Londrina, Brazil.
FAU - Forcato, Simone
AU  - Forcato S
FAU - Vidigal, Camila B
AU  - Vidigal CB
FAU - Loiola, Guilherme H
AU  - Loiola GH
FAU - Gerardin, Daniela C C
AU  - Gerardin DCC
FAU - Ceravolo, Graziela S
AU  - Ceravolo GS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Hypoglycemic Agents)
RN  - 169D1260KM (Nitroprusside)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Aorta, Thoracic/*drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hypoglycemic Agents/administration & dosage/adverse effects
MH  - Lactation/*drug effects/physiology
MH  - Male
MH  - Metformin/*administration & dosage/adverse effects
MH  - Nitroprusside/adverse effects
MH  - Organ Culture Techniques
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Vasoconstriction/*drug effects/physiology
MH  - Vasodilation/*drug effects/physiology
EDAT- 2017/07/22 06:00
MHDA- 2018/06/23 06:00
CRDT- 2017/07/22 06:00
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
PHST- 2017/07/22 06:00 [entrez]
AID - 10.1097/FJC.0000000000000520 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 2017 Nov;70(5):300-304. doi: 
      10.1097/FJC.0000000000000520.