PMID- 28732334
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20171010
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 173
DP  - 2017 Aug
TI  - Does laser phototherapy influence the proliferation of myoepithelial cells in the 
      salivary gland of hypothyroid rats?
PG  - 681-685
LID - S1011-1344(17)30601-2 [pii]
LID - 10.1016/j.jphotobiol.2017.07.008 [doi]
AB  - Thyroid hormones influence both development and growth of organs and tissues and 
      guarantee metabolic demands that interfere with the quality of digestive 
      secretions, including those of the salivary glands. Laser phototherapy - LPT can 
      modulate various biological phenomena and its diverse effects permit the action 
      on different cell types. The aim of this study was to evaluate the influence of 
      laser phototherapy on myoepithelial cells of salivary glands of hypothyroid rats. 
      Forty-two albino Wistar rats were divided into two main groups: euthyroid (EU) 
      and hypothyroid (HYPO). Hypothyroidism was induced using propylthiouracil (PTU) 
      for 4weeks. Each group was divided into subgroups: control (without laser) and 
      laser groups (Red/infrared - IR). LPT was used on the submandibular gland and was 
      carried out using a diode laser (lambda660 or lambda780nm, 40mW, spot size 0.04cm(2), 
      irradiation area 1cm(2), 300s, 6J/cm(2) per gland, 12J/cm(2) per session) and 
      started two weeks after PTU treatment. LPT was repeated every other day for two 
      weeks. After animal death, the glands were removed, dissected and processed for 
      immunohistochemical analysis. It was observed an increase in the number of 
      myoepithelial cells of hypothyroid control rats in comparison to euthyroid 
      controls (p=0.001). Visible LPT (lambda660nm) caused significant higher proliferation 
      of myoepithelial cells in EU rats when compared to IR LPT (lambda 780nm)(p</=0.001).It 
      is concluded that, despite the LPT protocol used did not influence myoepithelial 
      proliferation on hypothyroid rats it significantly increased the proliferation on 
      euthyroid animals.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Uzeda-E-Silva, Virginia Dias
AU  - Uzeda-E-Silva VD
AD  - Department of Propedeutics and Integrated Clinic, School of Dentistry, Federal 
      University of Bahia, Salvador, Brazil. Electronic address: 
      virginiauzeda@yahoo.com.br.
FAU - Rodriguez, Tania Tavares
AU  - Rodriguez TT
AD  - Department of Physiology, Health Sciences Center, Federal University of Bahia, 
      Salvador, Brazil.
FAU - Ramalho, Luciana Maria Pedreira
AU  - Ramalho LMP
AD  - Department of Propedeutics and Integrated Clinic, School of Dentistry, Federal 
      University of Bahia, Salvador, Brazil.
FAU - Xavier, Flavia Calo Aquino
AU  - Xavier FCA
AD  - Department of Propedeutics and Integrated Clinic, School of Dentistry, Federal 
      University of Bahia, Salvador, Brazil.
FAU - de Castro, Isabele Cardoso Vieira
AU  - de Castro ICV
AD  - Department of Propedeutics and Integrated Clinic, School of Dentistry, Federal 
      University of Bahia, Salvador, Brazil.
FAU - Pinheiro, Antonio Luiz Barbosa
AU  - Pinheiro ALB
AD  - Center of Biophotonics, School of Dentistry, Federal University of Bahia, 
      Salvador, Brazil.
FAU - Dos Santos, Jean Nunes
AU  - Dos Santos JN
AD  - Department of Propedeutics and Integrated Clinic, School of Dentistry, Federal 
      University of Bahia, Salvador, Brazil. Electronic address: jeanpatol@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170712
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 721M9407IY (Propylthiouracil)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/radiation effects
MH  - Disease Models, Animal
MH  - Epithelial Cells/cytology/metabolism/radiation effects
MH  - Hypothyroidism/chemically induced/pathology/*radiotherapy
MH  - Immunohistochemistry
MH  - Lasers, Semiconductor/*therapeutic use
MH  - Low-Level Light Therapy
MH  - Luminescent Measurements
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Propylthiouracil/toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Salivary Glands/*radiation effects
MH  - Thyroxine/blood
OTO - NOTNLM
OT  - Hypothyroidism
OT  - Laser phototherapy
OT  - Myoepithelial cell
OT  - Photobiomodulation
OT  - Submandibular gland
EDAT- 2017/07/22 06:00
MHDA- 2017/10/11 06:00
CRDT- 2017/07/22 06:00
PHST- 2017/05/03 00:00 [received]
PHST- 2017/07/06 00:00 [revised]
PHST- 2017/07/10 00:00 [accepted]
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/07/22 06:00 [entrez]
AID - S1011-1344(17)30601-2 [pii]
AID - 10.1016/j.jphotobiol.2017.07.008 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2017 Aug;173:681-685. doi: 
      10.1016/j.jphotobiol.2017.07.008. Epub 2017 Jul 12.