PMID- 28732559
OWN - NLM
STAT- MEDLINE
DCOM- 20180620
LR  - 20180620
IS  - 1532-3072 (Electronic)
IS  - 0040-8166 (Linking)
VI  - 49
IP  - 5
DP  - 2017 Oct
TI  - SOCS-1 is involved in TNF-alpha-induced mitochondrial dysfunction and apoptosis in 
      renal tubular epithelial cells.
PG  - 537-544
LID - S0040-8166(17)30089-7 [pii]
LID - 10.1016/j.tice.2017.06.005 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is suggested to induce mitochondrial dysfunction 
      and apoptosis of renal tubular epithelial cells that possibly exacerbates renal 
      function in chronic kidney disease (CKD). Here we investigated whether suppressor 
      of cytokine signaling-1 (SOCS-1), an inhibitor of cytokine signaling, was 
      involved in TNF-alpha-induced human renal tubular epithelial cells (HKCs) oxidative 
      stress and apoptosis. TNF-alpha promoted the protein and mRNA expression of SOCS-1 in 
      a time and dose dependent manner, along with increased cell apoptosis and 
      activation of apoptosis signal regulating kinase-1(ASK1) in HKCs. Furthermore, 
      overexpression of SOCS-1 in HKCs reduced TNF-alpha-mediated oxidative stress and 
      apoptosis. Meanwhile, We also found that overexpression of SOCS-1 could regulate 
      the activity of JAK/STAT signaling pathway. In addition, a specific JAK2 
      inhibitor, AG490, that both attenuated TNF-alpha-induced oxidative stress, also 
      reduced apoptosis. Taken together, overexpression of SOCS-1 prevented 
      TNF-alpha-mediated cell oxidative stress and apoptosis may be via suppression of 
      JAK/STAT signaling pathway activation in HKCs.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Du, Chunyang
AU  - Du C
AD  - Department of Pathology and Key Laboratory of Kidney Diseases of Hebei Province, 
      Hebei Medical University, Shijiazhuang, China.
FAU - Yao, Fang
AU  - Yao F
AD  - Department of Pathology and Key Laboratory of Kidney Diseases of Hebei Province, 
      Hebei Medical University, Shijiazhuang, China.
FAU - Ren, Yunzhuo
AU  - Ren Y
AD  - Department of Pathology and Key Laboratory of Kidney Diseases of Hebei Province, 
      Hebei Medical University, Shijiazhuang, China.
FAU - Du, Yunxia
AU  - Du Y
AD  - Department of Pathology and Key Laboratory of Kidney Diseases of Hebei Province, 
      Hebei Medical University, Shijiazhuang, China.
FAU - Wei, Jinying
AU  - Wei J
AD  - Department of Pathology and Key Laboratory of Kidney Diseases of Hebei Province, 
      Hebei Medical University, Shijiazhuang, China.
FAU - Wu, Haijiang
AU  - Wu H
AD  - Department of Pathology and Key Laboratory of Kidney Diseases of Hebei Province, 
      Hebei Medical University, Shijiazhuang, China.
FAU - Duan, Huijun
AU  - Duan H
AD  - Department of Pathology and Key Laboratory of Kidney Diseases of Hebei Province, 
      Hebei Medical University, Shijiazhuang, China. Electronic address: 
      duanhj999@163.com.
FAU - Shi, Yonghong
AU  - Shi Y
AD  - Department of Pathology and Key Laboratory of Kidney Diseases of Hebei Province, 
      Hebei Medical University, Shijiazhuang, China. Electronic address: 
      yonghongshi@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170630
PL  - Scotland
TA  - Tissue Cell
JT  - Tissue & cell
JID - 0214745
RN  - 0 (SOCS1 protein, human)
RN  - 0 (Suppressor of Cytokine Signaling 1 Protein)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Apoptosis/*physiology
MH  - Cell Line
MH  - Epithelial Cells/metabolism
MH  - Humans
MH  - Kidney Tubules/*metabolism
MH  - Mitochondria/*metabolism
MH  - Oxidative Stress/physiology
MH  - Suppressor of Cytokine Signaling 1 Protein/*metabolism
MH  - Tumor Necrosis Factor-alpha/*metabolism
OTO - NOTNLM
OT  - Apoptosis
OT  - HKC
OT  - Mitochondrial dysfunction
OT  - SOCS-1
OT  - TNF-alpha
EDAT- 2017/07/25 06:00
MHDA- 2018/06/21 06:00
CRDT- 2017/07/23 06:00
PHST- 2017/03/15 00:00 [received]
PHST- 2017/06/09 00:00 [revised]
PHST- 2017/06/29 00:00 [accepted]
PHST- 2017/07/25 06:00 [pubmed]
PHST- 2018/06/21 06:00 [medline]
PHST- 2017/07/23 06:00 [entrez]
AID - S0040-8166(17)30089-7 [pii]
AID - 10.1016/j.tice.2017.06.005 [doi]
PST - ppublish
SO  - Tissue Cell. 2017 Oct;49(5):537-544. doi: 10.1016/j.tice.2017.06.005. Epub 2017 
      Jun 30.