PMID- 28733878
OWN - NLM
STAT- MEDLINE
DCOM- 20180820
LR  - 20180820
IS  - 1661-4917 (Electronic)
IS  - 0004-069X (Linking)
VI  - 66
IP  - 1
DP  - 2018 Feb
TI  - Role of TGF-beta in Self-Peptide Regulation of Autoimmunity.
PG  - 11-19
LID - 10.1007/s00005-017-0482-6 [doi]
AB  - Transforming growth factor (TGF)-beta has been implicated in regulation of the 
      immune system, including autoimmunity. We have found that TGF-beta is readily 
      produced by T cells following immunization with self-peptide epitopes that 
      downregulate autoimmune responses in type 1 diabetes (T1D) prone nonobese 
      diabetic (NOD) mice. These include multiple peptide epitopes derived from the 
      islet beta-cell antigens GAD65 (GAD65 p202-221, GAD65 p217-236), GAD67 (GAD67 
      p210-229, GAD67 p225-244), IGRP (IGRP p123-145, IGRP p195-214) and insulin 
      B-chain (Ins. B:9-23) that protected NOD mice from T1D. Immunization of NOD mice 
      with the self-MHC class II I-A(g7) beta-chain-derived peptide, I-Abeta(g7) p54-76 also 
      induced large amounts of TGF-beta and also protected these mice from diabetes 
      development. These results indicate that peptides derived from disease related 
      self-antigens and MHC class II molecules primarily induce TGF-beta producing 
      regulatory Th3 and Tr1-like cells. TGF-beta produced by these cells could enhance 
      the differentiation of induced regulatory iTreg and iTreg17 cells to prevent 
      induction and progression of autoimmune diseases. We therefore suggest that 
      peripheral immune tolerance could be induced and maintained by immunization with 
      self-peptides that induce TGF-beta producing T cells.
FAU - Singh, Bhagirath
AU  - Singh B
AUID- ORCID: 0000-0002-9792-8694
AD  - Department of Microbiology & Immunology, Centre for Human Immunology, University 
      of Western Ontario, London, ON, N6A 5C1, Canada. bsingh@uwo.ca.
AD  - Department of Microbiology and Immunology, University of Western Ontario, London, 
      ON, N6A 5C1, Canada. bsingh@uwo.ca.
AD  - Robarts Research Institute, University of Western Ontario, London, ON, N6A 5B7, 
      Canada. bsingh@uwo.ca.
FAU - Krawetz, Michael D
AU  - Krawetz MD
AD  - Department of Microbiology and Immunology, University of Western Ontario, London, 
      ON, N6A 5C1, Canada.
FAU - De Lima, Rachel M
AU  - De Lima RM
AD  - Department of Microbiology and Immunology, University of Western Ontario, London, 
      ON, N6A 5C1, Canada.
FAU - Mukherjee, Rinee
AU  - Mukherjee R
AD  - Department of Microbiology and Immunology, University of Western Ontario, London, 
      ON, N6A 5C1, Canada.
FAU - Chaturvedi, Pratibha
AU  - Chaturvedi P
AD  - Department of Microbiology and Immunology, University of Western Ontario, London, 
      ON, N6A 5C1, Canada.
FAU - Lee-Chan, Edwin
AU  - Lee-Chan E
AD  - Department of Microbiology and Immunology, University of Western Ontario, London, 
      ON, N6A 5C1, Canada.
FAU - Leiter, Edward H
AU  - Leiter EH
AD  - The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
FAU - Summers, Kelly L
AU  - Summers KL
AD  - Department of Microbiology & Immunology, Centre for Human Immunology, University 
      of Western Ontario, London, ON, N6A 5C1, Canada.
AD  - Department of Microbiology and Immunology, University of Western Ontario, London, 
      ON, N6A 5C1, Canada.
AD  - Lawson Health Research Institute, London, ON, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170721
PL  - Poland
TA  - Arch Immunol Ther Exp (Warsz)
JT  - Archivum immunologiae et therapiae experimentalis
JID - 0114365
RN  - 0 (Autoantigens)
RN  - 0 (Peptides)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Autoantigens/immunology
MH  - Autoimmunity
MH  - Diabetes Mellitus, Type 1/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunization
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Peptides/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Transforming Growth Factor beta/*metabolism
OTO - NOTNLM
OT  - Auto-antigens
OT  - NOD mice
OT  - Peptide epitopes
OT  - Regulatory T cells
OT  - TGF-beta
OT  - Type 1 diabetes
EDAT- 2017/07/25 06:00
MHDA- 2018/08/21 06:00
CRDT- 2017/07/23 06:00
PHST- 2017/03/29 00:00 [received]
PHST- 2017/06/19 00:00 [accepted]
PHST- 2017/07/25 06:00 [pubmed]
PHST- 2018/08/21 06:00 [medline]
PHST- 2017/07/23 06:00 [entrez]
AID - 10.1007/s00005-017-0482-6 [pii]
AID - 10.1007/s00005-017-0482-6 [doi]
PST - ppublish
SO  - Arch Immunol Ther Exp (Warsz). 2018 Feb;66(1):11-19. doi: 
      10.1007/s00005-017-0482-6. Epub 2017 Jul 21.