PMID- 28736117
OWN - NLM
STAT- MEDLINE
DCOM- 20180322
LR  - 20220330
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 38
DP  - 2017 Sep
TI  - Modulation of dendritic cell and T cell cross-talk during aging: The potential 
      role of checkpoint inhibitory molecules.
PG  - 40-51
LID - S1568-1637(17)30099-5 [pii]
LID - 10.1016/j.arr.2017.07.002 [doi]
AB  - Dendritic cells (DCs) undergo continuous changes throughout life, and there is 
      evidence that elderly DCs have a reduced capacity to stimulate T cells, which may 
      contribute to impaired anti-tumour immune responses in elderly people with 
      cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be 
      one mechanism that impairs the ability of elderly DCs to activate T cells. 
      However, little is currently known regarding the combined effects of aging and 
      cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss 
      our current understanding of the influence of aging and cancer on key DC and T 
      cell inhibitory molecules/pathways, the potential underlying cellular and 
      molecular mechanisms contributing to their modulation, and the possibility of 
      therapeutically targeting inhibitory molecules in elderly cancer patients.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Gardner, Joanne K
AU  - Gardner JK
AD  - School of Biomedical Sciences, Curtin University, Kent Street, Bentley, Western 
      Australia 6102, Australia; Curtin Health Innovation Research Institute, Kent 
      Street, Bentley, Western Australia 6102, Australia.
FAU - Mamotte, Cyril D S
AU  - Mamotte CDS
AD  - School of Biomedical Sciences, Curtin University, Kent Street, Bentley, Western 
      Australia 6102, Australia; Curtin Health Innovation Research Institute, Kent 
      Street, Bentley, Western Australia 6102, Australia.
FAU - Jackaman, Connie
AU  - Jackaman C
AD  - School of Biomedical Sciences, Curtin University, Kent Street, Bentley, Western 
      Australia 6102, Australia; Curtin Health Innovation Research Institute, Kent 
      Street, Bentley, Western Australia 6102, Australia.
FAU - Nelson, Delia J
AU  - Nelson DJ
AD  - School of Biomedical Sciences, Curtin University, Kent Street, Bentley, Western 
      Australia 6102, Australia; Curtin Health Innovation Research Institute, Kent 
      Street, Bentley, Western Australia 6102, Australia. Electronic address: 
      Delia.Nelson@curtin.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170720
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Aging/*immunology
MH  - Dendritic Cells/*metabolism
MH  - Humans
MH  - Neoplasms/immunology
MH  - *Receptor Cross-Talk
MH  - T-Lymphocytes/*metabolism
OTO - NOTNLM
OT  - Aging
OT  - Cancer
OT  - Dendritic cells
OT  - Inhibitory molecules
EDAT- 2017/07/25 06:00
MHDA- 2018/03/23 06:00
CRDT- 2017/07/25 06:00
PHST- 2017/05/02 00:00 [received]
PHST- 2017/06/17 00:00 [revised]
PHST- 2017/07/17 00:00 [accepted]
PHST- 2017/07/25 06:00 [pubmed]
PHST- 2018/03/23 06:00 [medline]
PHST- 2017/07/25 06:00 [entrez]
AID - S1568-1637(17)30099-5 [pii]
AID - 10.1016/j.arr.2017.07.002 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2017 Sep;38:40-51. doi: 10.1016/j.arr.2017.07.002. Epub 2017 Jul 
      20.