PMID- 28736262
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20181018
IS  - 1095-8584 (Electronic)
IS  - 0022-2828 (Linking)
VI  - 110
DP  - 2017 Sep
TI  - BDNF - A key player in cardiovascular system.
PG  - 54-60
LID - S0022-2828(17)30161-X [pii]
LID - 10.1016/j.yjmcc.2017.07.007 [doi]
AB  - Neurotrophins (NTs) were first identified as target-derived survival factors for 
      neurons of the central and peripheral nervous system (PNS). They are known to 
      control neural cell fate, development and function. Independently of their 
      neuronal properties, NTs exert unique cardiovascular activity. The heart is 
      innervated by sensory, sympathetic and parasympathetic neurons, which require NTs 
      during early development and in the establishment of mature properties, 
      contributing to the maintenance of cardiovascular homeostasis. The identification 
      of molecular mechanisms regulated by NTs and involved in the crosstalk between 
      cardiac sympathetic nerves, cardiomyocytes, cardiac fibroblasts, and vascular 
      cells, has a fundamental importance in both normal heart function and disease. 
      The article aims to review the recent data on the effects of Brain-Derived 
      Neurotrophic Factor (BDNF) on various cardiovascular neuronal and non-neuronal 
      functions such as the modulation of synaptic properties of autonomic neurons, 
      axonal outgrowth and sprouting, formation of the vascular and neural networks, 
      smooth muscle migration, and control of endothelial cell survival and 
      cardiomyocytes. Understanding these mechanisms may be crucial for developing 
      novel therapeutic strategies, including stem cell-based therapies.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Pius-Sadowska, Ewa
AU  - Pius-Sadowska E
AD  - Department of General Pathology, Pomeranian Medical University, Szczecin, Poland.
FAU - Machalinski, Boguslaw
AU  - Machalinski B
AD  - Department of General Pathology, Pomeranian Medical University, Szczecin, Poland. 
      Electronic address: machalin@pum.edu.pl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170721
PL  - England
TA  - J Mol Cell Cardiol
JT  - Journal of molecular and cellular cardiology
JID - 0262322
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cardiovascular System/innervation/*metabolism/pathology
MH  - Heart/embryology/physiology
MH  - Humans
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - BDNF
OT  - Cardiovascular niche
OT  - Heart homeostasis
OT  - Neuroprotection
EDAT- 2017/07/25 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/07/25 06:00
PHST- 2017/02/15 00:00 [received]
PHST- 2017/07/18 00:00 [revised]
PHST- 2017/07/19 00:00 [accepted]
PHST- 2017/07/25 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2017/07/25 06:00 [entrez]
AID - S0022-2828(17)30161-X [pii]
AID - 10.1016/j.yjmcc.2017.07.007 [doi]
PST - ppublish
SO  - J Mol Cell Cardiol. 2017 Sep;110:54-60. doi: 10.1016/j.yjmcc.2017.07.007. Epub 
      2017 Jul 21.