PMID- 28736375
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200612
IS  - 1673-4254 (Print)
IS  - 2663-0842 (Electronic)
IS  - 1673-4254 (Linking)
VI  - 37
IP  - 7
DP  - 2017 Jul 20
TI  - [Expression of vasohibin-1 and MACC1 in lung squamous cell carcinoma and their 
      clinicopathological significance].
PG  - 952-956
AB  - OBJECTIVE: To investigate the expressions of vasohibin-1 and MACC1 in lung 
      squamous cell carcinoma (LSCC) and their associations with the 
      clinicopathological characteristics of the patients. METHODS: The expressions of 
      vasohibin-1 and MACC1 proteins were examined with immunohistochemistry in 160 
      LSCC tissues and 80 normal lung tissues. RESULTS: The positivity rates of 
      vasohibin-1 and MACC1 proteins were 59.4% and 11.3% in LSCC tissues, 
      respectively, which were significantly higher than the rates in normal lung 
      tissues (57.5% and 8.8%, respectively; P<0.05). The expressions of vasohibin-1 
      and MACC1 proteins were significantly correlated with the tumor grades, lymph 
      node metastasis, and TNM stages (all P<0.05). Spearman correlation analysis 
      indicated a positive correlation between vasohibin-1 expression and MACC1 
      expressions (P<0.001). Kaplan-Meier survival analysis showed that LSCC patients 
      with a positive expression of vasohibin-1 had significantly shorter overall 
      survival time than those negative for vasohibin-1; the overall survival time was 
      also significantly shorter in patients positive for MACC1 than in those negative 
      for MACC1 (both P<0.05). Multivariate COX regression analysis indicated that 
      positive expressions of vasohibin-1 and MACC1 protein and TNM stage were 
      independent prognostic factors of LSCC. CONCLUSION: Aberrant expressions of 
      vasohibin-1 and MACC1 may participate in the development and promote invasion and 
      metastasis of LSCC. The combined detection of vasohibin-1 and MACC1 expression 
      may provide important evidence for predicting the progression and prognosis of 
      LSCC.
FAU - Wu, Shi-Wu
AU  - Wu SW
AD  - Department of Pathology, First Affiliated Hospital of Bengbu Medical 
      College/Department of Pathology, Bengbu Medical College, Bengbu 233004, 
      China.E-mail: 573448542@qq.com.
FAU - Wang, Yi-Chao
AU  - Wang YC
FAU - Ci, Hong-Fei
AU  - Ci HF
FAU - Tao, Yi-Sheng
AU  - Tao YS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
PMC - PMC6765526
EDAT- 2017/07/25 06:00
MHDA- 2017/07/25 06:01
PMCR- 2017/07/20
CRDT- 2017/07/25 06:00
PHST- 2017/07/25 06:00 [entrez]
PHST- 2017/07/25 06:00 [pubmed]
PHST- 2017/07/25 06:01 [medline]
PHST- 2017/07/20 00:00 [pmc-release]
AID - nfykdxxb-37-7-952 [pii]
AID - 10.3969/j.issn.1673-4254.2017.07.18 [doi]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2017 Jul 20;37(7):952-956. doi: 
      10.3969/j.issn.1673-4254.2017.07.18.