PMID- 28737018 OWN - NLM STAT- MEDLINE DCOM- 20190628 LR - 20231112 IS - 1522-2586 (Electronic) IS - 1053-1807 (Print) IS - 1053-1807 (Linking) VI - 47 IP - 3 DP - 2018 Mar TI - Increased myocardial native T(1) relaxation time in patients with nonischemic dilated cardiomyopathy with complex ventricular arrhythmia. PG - 779-786 LID - 10.1002/jmri.25811 [doi] AB - PURPOSE: To study the relationship between diffuse myocardial fibrosis and complex ventricular arrhythmias (ComVA) in patients with nonischemic dilated cardiomyopathy (NICM). We hypothesized that NICM patients with ComVA would have a higher native myocardial T(1) time, suggesting more extensive myocardial diffuse fibrosis. MATERIALS AND METHODS: We prospectively enrolled NICM patients with a history of ComVA (n = 50) and age-matched NICM patients without ComVA (n = 57). Imaging was performed at 1.5T with a protocol that included cine magnetic resonance imaging (MRI) for left ventricular (LV) function, late gadolinium enhancement (LGE) for focal scar, and native T(1) mapping for diffuse fibrosis assessment. RESULTS: Global native T(1) time was significantly higher in patients with NICM with ComVA when compared to patients with NICM without ComVA (1131 +/- 42 vs. 1107 +/- 45 msec, P = 0.006), and this finding remained after excluding segments with scar on LGE (1124 +/- 36 vs. 1102 +/- 44 msec, P = 0.006). Native T(1) was similar in NICM patients with and without the presence of LGE (1121 +/- 39 vs. 1117 +/- 48 msec, P = 0.68) and mildly correlated with LV end-diastolic volume index (r = 0.27, P = 0.005), LV end-systolic volume index (r = 0.24, P = 0.01), and LV ejection fraction (r = -0.28, P = 0.003). Native T(1) value for each 10-msec increment was an independent predictor of ComVA (odds ratio 1.14, 95% confidence interval 1.03-1.25; P = 0.008) beyond LV function and LGE. CONCLUSION: NICM patients with ComVA have higher native T(1) compared to NICM without any documented ComVA. Native myocardial T(1) is independently associated with ComVA, after adjusting for LV function and LGE. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:779-786. In memoriam: The authors are grateful for Dr. Josephson's inspiring guidance and contributions to this study. CI - (c) 2017 International Society for Magnetic Resonance in Medicine. FAU - Nakamori, Shiro AU - Nakamori S AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. FAU - Bui, An H AU - Bui AH AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. AD - Harvard-Thorndike Electrophysiology Institute, Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. FAU - Jang, Jihye AU - Jang J AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. FAU - El-Rewaidy, Hossam A AU - El-Rewaidy HA AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. FAU - Kato, Shingo AU - Kato S AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. FAU - Ngo, Long H AU - Ngo LH AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. FAU - Josephson, Mark E AU - Josephson ME AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. AD - Harvard-Thorndike Electrophysiology Institute, Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. FAU - Manning, Warren J AU - Manning WJ AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. FAU - Nezafat, Reza AU - Nezafat R AD - Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - R01 EB008743/EB/NIBIB NIH HHS/United States GR - R01 HL129157/HL/NHLBI NIH HHS/United States GR - R01 HL129185/HL/NHLBI NIH HHS/United States GR - R21 HL127650/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20170724 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Arrhythmias, Cardiac/*complications/diagnostic imaging/*physiopathology MH - Cardiomyopathy, Dilated/complications/*diagnostic imaging/*physiopathology MH - Contrast Media MH - Female MH - Gadolinium MH - Heart/diagnostic imaging/physiopathology MH - Humans MH - Image Enhancement/methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Prospective Studies MH - Young Adult PMC - PMC5967630 MID - NIHMS928654 OTO - NOTNLM OT - diffuse myocardial fibrosis. ventricular arrhythmia OT - native T1 mapping OT - nonischemic dilated cardiomyopathy EDAT- 2017/07/25 06:00 MHDA- 2019/06/30 06:00 PMCR- 2019/03/01 CRDT- 2017/07/25 06:00 PHST- 2016/10/19 00:00 [received] PHST- 2017/06/21 00:00 [accepted] PHST- 2017/07/25 06:00 [pubmed] PHST- 2019/06/30 06:00 [medline] PHST- 2017/07/25 06:00 [entrez] PHST- 2019/03/01 00:00 [pmc-release] AID - 10.1002/jmri.25811 [doi] PST - ppublish SO - J Magn Reson Imaging. 2018 Mar;47(3):779-786. doi: 10.1002/jmri.25811. Epub 2017 Jul 24.