PMID- 28737124
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20201209
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 36
IP  - 5
DP  - 2017 Sep/Oct
TI  - Distribution and expression of brain-derived neurotrophic factor, nerve growth 
      factor, and neurotrophic factor-3 in refractory epilepsy-associated focal 
      cortical dysplasia.
PG  - 233-239
LID - 10.5414/NP301026 [doi]
AB  - OBJECTIVE: To investigate the expression and distribution of brain-derived 
      neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophic factor-3 
      (NT-3) in refractory epilepsy-associated type I focal cortical dysplasia (FCD I) 
      and FCD IIA patients, and to explore their effects on pathogenesis of FCD I and 
      FCD IIA. MATERIALS AND METHODS: 19 subjects who received surgery at the 
      Department of Neurosurgery, First Affiliated Hospital, Fujian Medical University, 
      China between June 2010 and May 2012, were enrolled in this study. They were 
      pathologically diagnosed as FCD IIA (n = 7) and FCD I (n = 12) after surgery and 
      were considered as two experimental groups. Temporal lobe samples of 10 subjects 
      who had suffered craniocerebral injury but did not have nervous system disease 
      were collected as a control group. Immunohistochemical methods and Western blot 
      assays were used to detect the expression and distribution of BDNF, NGF, and NT-3 
      in temporal lobes, and differences in their expression and distribution were 
      compared between experimental and control groups. RESULTS: BDNF expression was 
      slightly higher in the FCD IIA group compared to that in the FCD I group and was 
      significantly greater when compared with the control group. Compared with the 
      control group, NGF and NT-3 expression was higher in the FCD groups. However, no 
      significant difference was observed between the FCD IIA and FCD I group. 
      CONCLUSION: Abnormal distribution and expression of BDNF, NGF, and NT-3 may play 
      an important role in the mechanism of FCD I and FCD IIA-induced epilepsy.
.
FAU - Wang, Feng
AU  - Wang F
FAU - Lin, Yuanxiang
AU  - Lin Y
FAU - Kang, Dezhi
AU  - Kang D
FAU - Chen, Fuxiang
AU  - Chen F
FAU - Lin, Kun
AU  - Lin K
FAU - Su, Xingfen
AU  - Su X
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NGF protein, human)
RN  - 0 (NTF3 protein, human)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Drug Resistant Epilepsy/etiology/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Malformations of Cortical Development/complications/*metabolism
MH  - Nerve Growth Factor/*biosynthesis
MH  - Nerve Growth Factors/*biosynthesis
MH  - Neurotrophin 3
MH  - Young Adult
EDAT- 2017/07/25 06:00
MHDA- 2018/08/28 06:00
CRDT- 2017/07/25 06:00
PHST- 2017/09/06 00:00 [accepted]
PHST- 2017/07/25 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
PHST- 2017/07/25 06:00 [entrez]
AID - 15984 [pii]
AID - 10.5414/NP301026 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2017 Sep/Oct;36(5):233-239. doi: 10.5414/NP301026.