PMID- 28737932
OWN - NLM
STAT- MEDLINE
DCOM- 20190102
LR  - 20200225
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Print)
IS  - 1936-0851 (Linking)
VI  - 11
IP  - 8
DP  - 2017 Aug 22
TI  - Ins and Outs in Environmental and Occupational Safety Studies of Asthma and 
      Engineered Nanomaterials.
PG  - 7565-7571
LID - 10.1021/acsnano.7b04916 [doi]
AB  - According to the Centers for Disease Control and Prevention, approximately 25 
      million Americans suffer from asthma. The disease total annual cost is about $56 
      billion and includes both the direct and indirect costs of medications, hospital 
      stays, missed work, and decreased productivity. Air pollution with xenobiotics, 
      bacterial agents, and industrial nanomaterials, such as carbon nanotubes, 
      contribute to the exacerbation of this condition and are a point of particular 
      attention in environmental toxicology as well as in occupational health and 
      safety research. Mast cell degranulation and activation of Th(2) cells triggered 
      either by allergen-specific immunoglobulin E (IgE) or by alternative mechanisms, 
      such as locally produced neurotransmitters, underlie the pathophysiological 
      process of airway constriction during an asthma attack. Other immune and 
      non-immune cell types, including basophils, eosinophils, Th(1), Th(17), Th(9), 
      macrophages, dendritic cells, and smooth muscle cells, are involved in the 
      inflammatory and allergic responses during asthma, which, under chronic 
      conditions, may progress without mast cells, the key trigger of the acute asthma 
      attack. To decipher complex molecular, cellular, and genetic mechanisms, many 
      researchers have attempted to develop in vitro and in vivo models to study 
      asthma. Herein, we summarize the advantages and disadvantages of various models 
      and their applicability to nanoparticle evaluation in asthma research. We further 
      suggest that a framework for both in vitro and in vivo methods should be used to 
      study the impact of engineered nanomaterials on asthma etiology, pathophysiology, 
      and treatment.
FAU - Dobrovolskaia, Marina A
AU  - Dobrovolskaia MA
AD  - Nanotechnology Characterization Laboratory, Cancer Research Technology Program, 
      Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer 
      Research, NCI at Frederick , Frederick, Maryland 21702, United States.
FAU - Shurin, Michael R
AU  - Shurin MR
AD  - Department of Pathology, University of Pittsburgh Medical Center , Pittsburgh, 
      Pennsylvania 15213, United States.
AD  - Department of Immunology, University of Pittsburgh Medical Center , Pittsburgh, 
      Pennsylvania 15213, United States.
FAU - Kagan, Valerian E
AU  - Kagan VE
AUID- ORCID: 0000-0002-7245-1885
AD  - Departments of Environmental and Occupational Health, Pharmacology and Chemical 
      Biology, Chemistry and Radiation Oncology and Center for Free and Antioxidant 
      Health, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
FAU - Shvedova, Anna A
AU  - Shvedova AA
AD  - Health Effects Laboratory Division, National Institute of Occupational Safety and 
      Health, Centers for Disease Control and Prevention , Morgantown, West Virginia 
      26505, United States.
AD  - Department of Physiology and Pharmacology, West Virginia University , Morgantown, 
      West Virginia 26506, United States.
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170724
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (Nanotubes, Carbon)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Asthma
MH  - Basophils/metabolism
MH  - Eosinophils/metabolism
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Mast Cells
MH  - Myocytes, Smooth Muscle/metabolism
MH  - Nanostructures/*chemistry
MH  - Nanotubes, Carbon/*chemistry
MH  - Occupational Health
MH  - Th1 Cells/metabolism
MH  - Th17 Cells/metabolism
MH  - Th2 Cells/metabolism
PMC - PMC6481664
MID - NIHMS1011345
EDAT- 2017/07/25 06:00
MHDA- 2019/01/03 06:00
PMCR- 2019/04/24
CRDT- 2017/07/25 06:00
PHST- 2017/07/25 06:00 [pubmed]
PHST- 2019/01/03 06:00 [medline]
PHST- 2017/07/25 06:00 [entrez]
PHST- 2019/04/24 00:00 [pmc-release]
AID - 10.1021/acsnano.7b04916 [doi]
PST - ppublish
SO  - ACS Nano. 2017 Aug 22;11(8):7565-7571. doi: 10.1021/acsnano.7b04916. Epub 2017 
      Jul 24.