PMID- 28738166
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 95
IP  - 11
DP  - 2017 Nov
TI  - Ablation of toll-like receptor 4 mitigates cardiac mitochondrial dysfunction in 
      hyperhomocysteinemia.
PG  - 1369-1375
LID - 10.1139/cjpp-2016-0744 [doi]
AB  - Hyperhomocysteinemia (HHcy) is a risk factor for adverse cardiovascular events; 
      however, the mechanism for development of this disease is still unknown. 
      Toll-like receptor 4 (TRL4) is a molecule involved in the immune response pathway 
      and is quickly becoming a receptor of interest in the field of hypertension. In 
      this study, we hypothesized that ablation of TLR4 mitigates cardiac mitochondrial 
      dysfunction in a model of HHcy. Five strains of mice (C57BL/6J, CBS(+/-), C3H, 
      CBS(+/-)/C3H, and C3H/HeOuJ) 10-12 weeks old were utilized. We found that HHcy 
      causes heart hypertrophy and promotes oxidative stress while mice with HHcy and 
      inactivated TLR4 showed significant improvement in examined parameters. A 
      dominance of endothelial cell mitochondrial fission over mitochondrial fusion in 
      HHcy and oxidative stress was observed, which may explain the endothelial cell 
      loss and dysfunction that contributes to inward cardiac remodeling.
FAU - Jeremic, Nevena
AU  - Jeremic N
AD  - Health Sciences Centre, Department of Physiology, School of Medicine, University 
      of Louisville, 500 South Preston Street, Louisville, KY 40202, USA.
AD  - Health Sciences Centre, Department of Physiology, School of Medicine, University 
      of Louisville, 500 South Preston Street, Louisville, KY 40202, USA.
FAU - Weber, Gregory J
AU  - Weber GJ
AD  - Health Sciences Centre, Department of Physiology, School of Medicine, University 
      of Louisville, 500 South Preston Street, Louisville, KY 40202, USA.
AD  - Health Sciences Centre, Department of Physiology, School of Medicine, University 
      of Louisville, 500 South Preston Street, Louisville, KY 40202, USA.
FAU - Tyagi, Suresh C
AU  - Tyagi SC
AD  - Health Sciences Centre, Department of Physiology, School of Medicine, University 
      of Louisville, 500 South Preston Street, Louisville, KY 40202, USA.
AD  - Health Sciences Centre, Department of Physiology, School of Medicine, University 
      of Louisville, 500 South Preston Street, Louisville, KY 40202, USA.
LA  - eng
PT  - Journal Article
DEP - 20170724
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Animals
MH  - *Gene Deletion
MH  - Genotype
MH  - Hyperhomocysteinemia/*genetics/metabolism/*pathology
MH  - Hypertrophy/metabolism/pathology
MH  - Mice
MH  - Mitochondria, Heart/metabolism/*pathology
MH  - Mitochondrial Dynamics
MH  - Myocardium/metabolism/pathology
MH  - Oxidative Stress/genetics
MH  - Toll-Like Receptor 4/*deficiency/*genetics
OTO - NOTNLM
OT  - coeur
OT  - heart
OT  - homocysteine
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - hyperhomocysteinemie
OT  - mitochondria
OT  - mitochondrie
OT  - recepteur de type Toll 4
OT  - toll-like receptor 4
EDAT- 2017/07/25 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/07/25 06:00
PHST- 2017/07/25 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/07/25 06:00 [entrez]
AID - 10.1139/cjpp-2016-0744 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2017 Nov;95(11):1369-1375. doi: 10.1139/cjpp-2016-0744. 
      Epub 2017 Jul 24.