PMID- 28739050
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20180507
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 43
DP  - 2017 Jul
TI  - Reduced water intake deteriorates glucose regulation in patients with type 2 
      diabetes.
PG  - 25-32
LID - S0271-5317(17)30048-9 [pii]
LID - 10.1016/j.nutres.2017.05.004 [doi]
AB  - Epidemiological research has demonstrated that low daily total water intake is 
      associated with increased diagnosis of hyperglycemia. Possible mechanisms for 
      this increase include hormones related to the hypothalamic pituitary axis as well 
      as the renin-angiotensin-aldosterone system (RAAS). Therefore, the hypothesis of 
      the present study was that acute low water intake would result in differential 
      hormonal profiles and thus impaired blood glucose regulation during an oral 
      glucose tolerance test (OGTT) in people with type 2 diabetes mellitus (T2DM). 
      Nine men (53 +/- 9 years, 30.0 +/- 4.3 m∙kg(-2), 32% +/- 6% body fat) diagnosed with 
      T2DM completed OGTTs in euhydrated (EUH) and hypohydrated (HYP) states in 
      counterbalanced order. Water restriction led to hypohydration of -1.6% of body 
      weight, with elevated plasma (EUH: 288 +/- 4, HYP: 298 +/- 6 mOsm.kg(-1); P < .05) 
      and urine (EUH: 512 +/- 185, HYP: 994 +/- 415 mOsm.kg(-1); P < .05) osmolality. There 
      was a significant main effect of condition for serum glucose (at time 0 minute 
      9.5 +/- 4.2 vs 10.4 +/- 4.4 mmol∙L(-1) and at time 120 minutes 19.1 +/- 4.8 vs 21.0 +/- 
      4.1 mmol∙L(-1) for EUH and HYP, respectively; P < .001) but not insulin (mean 
      difference between EUH and HYP -12.1 +/- 44.9 pmol∙L(-1), P = .390). An interaction 
      between time and condition was observed for cortisol: decrease from minute 0 to 
      120 in EUH (-85.3 +/- 82.1 nmol∙L(-1)) vs HYP (-25.0 +/- 43.0 nmol∙L(-1); P = .017). 
      No differences between conditions were found within RAAS-related hormones. 
      Therefore, we can conclude that 3 days of low total water intake in people with 
      T2DM acutely impairs blood glucose response during an OGTT via cortisol but not 
      RAAS-mediated glucose regulation.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Johnson, Evan C
AU  - Johnson EC
AD  - University of Arkansas, Hydration Science Lab, 155 Stadium Dr, Fayetteville, AR 
      72701, USA.
FAU - Bardis, Costas N
AU  - Bardis CN
AD  - University of Arkansas, Hydration Science Lab, 155 Stadium Dr, Fayetteville, AR 
      72701, USA.
FAU - Jansen, Lisa T
AU  - Jansen LT
AD  - University of Arkansas, Hydration Science Lab, 155 Stadium Dr, Fayetteville, AR 
      72701, USA.
FAU - Adams, J D
AU  - Adams JD
AD  - University of Arkansas, Hydration Science Lab, 155 Stadium Dr, Fayetteville, AR 
      72701, USA.
FAU - Kirkland, Tracie W
AU  - Kirkland TW
AD  - University of Arkansas, Hydration Science Lab, 155 Stadium Dr, Fayetteville, AR 
      72701, USA.
FAU - Kavouras, Stavros A
AU  - Kavouras SA
AD  - University of Arkansas, Hydration Science Lab, 155 Stadium Dr, Fayetteville, AR 
      72701, USA; Division of Endocrinology, University of Arkansas for Medical 
      Sciences, Little Rock, AR, USA. Electronic address: kavouras@uark.edu.
LA  - eng
PT  - Journal Article
DEP - 20170517
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Body Weight
MH  - Diabetes Mellitus, Type 2/*blood
MH  - *Drinking
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Organism Hydration Status
MH  - Osmolar Concentration
MH  - Pilot Projects
MH  - Renin-Angiotensin System
OTO - NOTNLM
OT  - Drinking
OT  - Hyperglycemia
OT  - Osmolar concentration
OT  - Vasopressin
EDAT- 2017/07/26 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/01/17 00:00 [received]
PHST- 2017/04/14 00:00 [revised]
PHST- 2017/05/10 00:00 [accepted]
PHST- 2017/07/26 06:00 [entrez]
PHST- 2017/07/26 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
AID - S0271-5317(17)30048-9 [pii]
AID - 10.1016/j.nutres.2017.05.004 [doi]
PST - ppublish
SO  - Nutr Res. 2017 Jul;43:25-32. doi: 10.1016/j.nutres.2017.05.004. Epub 2017 May 17.