PMID- 28739730
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20181202
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Comparison of Different Muscle-Relaxant Anesthetics on Growth, Migration and 
      Invasion of Gastric Cancer Cells.
PG  - 4371-4378
AB  - BACKGROUND/AIM: Muscle relaxants, also known as neuromuscular blocking agents, 
      can block nerve impulses to the muscles and are always used in surgery for 
      general anesthesia. However, the effect of muscle-relaxant anesthetics on cell 
      activity in gastric cancer is currently unknown. The present study aimed to 
      examine and compare the role of three different muscle-relaxant anesthetics in 
      gastric cancer cells. MATERIALS AND METHODS: Gastric cancer cells (SGC7901 and 
      BGC 823) were treated with a different dose of muscle-relaxant anesthetics, 
      Rocuronium bromide (Rb), Vecuronium bromide (Vb) and Cisatracurium Besilate (CB). 
      Using in vitro models, the effects on gastric cancer cell invasion, growth and 
      migration of various anesthetics were subsequently investigated. RESULTS: We 
      found that Rb increased the growth, invasion and migration of gastric cancer 
      cells SGC7901 and BGC823. However, Vb and CB, as relatively mitigative 
      anesthetics, did not significantly affect gastric cancer cell malignant phenotype 
      at their regular blood concentration. CONCLUSION: Our results are important in 
      selecting the type and dose of anesthetic used for surgery of gastric cancer 
      patients. An understanding of the effect of muscle-relaxant anesthetics and their 
      impact on tumor metastasis is critical, since it provides insight into the 
      appropriate anesthetic strategy that could improve long-term survival in some 
      patients with gastric cancer.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Jiang, Aihua
AU  - Jiang A
AD  - Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
FAU - Zhao, Huishan
AU  - Zhao H
AD  - Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
FAU - Liu, Xiaofei
AU  - Liu X
AD  - Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
FAU - Yu, Mingwei
AU  - Yu M
AD  - Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
FAU - Chen, Jian
AU  - Chen J
AD  - Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
FAU - Jiang, Wen G
AU  - Jiang WG
AD  - Cardiff-China Medical Research Collaborative, Cardiff University School of 
      Medicine, Cardiff, U.K. jiangw@cardiff.ac.uk.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Androstanols)
RN  - 0 (Neuromuscular Blocking Agents)
RN  - 2GQ1IRY63P (Atracurium)
RN  - 7E4PHP5N1D (Vecuronium Bromide)
RN  - QX62KLI41N (cisatracurium)
RN  - WRE554RFEZ (Rocuronium)
SB  - IM
MH  - Androstanols/*adverse effects/pharmacology
MH  - Atracurium/adverse effects/*analogs & derivatives/pharmacology
MH  - Cell Adhesion/drug effects
MH  - Cell Line, Tumor
MH  - Cell Movement/drug effects
MH  - Cell Proliferation/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Neoplasm Invasiveness
MH  - Neuromuscular Blocking Agents/*adverse effects/pharmacology
MH  - Rocuronium
MH  - Stomach Neoplasms/*pathology
MH  - Vecuronium Bromide/*adverse effects/pharmacology
OTO - NOTNLM
OT  - Anesthetics
OT  - CB
OT  - Rb
OT  - Vb
OT  - breast cancer
OT  - invasion
OT  - migration
EDAT- 2017/07/26 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/05/19 00:00 [received]
PHST- 2017/05/31 00:00 [revised]
PHST- 2017/06/01 00:00 [accepted]
PHST- 2017/07/26 06:00 [entrez]
PHST- 2017/07/26 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
AID - 37/8/4371 [pii]
AID - 10.21873/anticanres.11831 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4371-4378. doi: 10.21873/anticanres.11831.