PMID- 28740148
OWN - NLM
STAT- MEDLINE
DCOM- 20190225
LR  - 20190225
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jul 24
TI  - Incremental benefit of late gadolinium cardiac magnetic resonance imaging for 
      risk stratification in patients with hypertrophic cardiomyopathy.
PG  - 6336
LID - 10.1038/s41598-017-06533-0 [doi]
LID - 6336
AB  - Hypertrophic cardiomyopathy (HCM) has a low risk for sudden cardiac death (SCD). 
      The ESC clinical risk prediction model estimates the risk of SCD using clinical 
      and echocardiographical parameters without taking into account cardiac magnetic 
      resonance (CMR) parameters. Therefore, we compared the CMR characteristics of 149 
      patients with low, intermediate and high ESC risk scores. In these patients left 
      and right ventricular ejection fraction and volumes were comparable. Patients 
      with a high ESC risk score revealed a significantly higher extent of late 
      gadolinium enhancement (LGE) compared to patients with intermediate or a low risk 
      scores. During follow-up of 4 years an extent of LGE >/=20% identified patients at 
      a higher risk for major adverse cardiac arrhythmic events in the low and 
      intermediate ESC risk group whereas an extent of LGE <20% was associated with a 
      low risk of major adverse cardiac arrhythmic events despite a high ESC risk 
      score >/=6%. Hence, we hypothesize that the extent of fibrosis might be an 
      additional risk marker.
FAU - Doesch, Christina
AU  - Doesch C
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Tulumen, Erol
AU  - Tulumen E
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany. erol.tueluemen@umm.de.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany. 
      erol.tueluemen@umm.de.
FAU - Akin, Ibrahim
AU  - Akin I
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Rudic, Boris
AU  - Rudic B
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Kuschyk, Juergen
AU  - Kuschyk J
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - El-Battrawy, Ibrahim
AU  - El-Battrawy I
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Becher, Tobias
AU  - Becher T
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Budjan, Johannes
AU  - Budjan J
AD  - Department of Radiology and Nuclear Medicine, University Medical Centre Mannheim, 
      Mannheim, Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Smakic, Arman
AU  - Smakic A
AD  - Department of Radiology and Nuclear Medicine, University Medical Centre Mannheim, 
      Mannheim, Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Schoenberg, Stefan O
AU  - Schoenberg SO
AD  - Department of Radiology and Nuclear Medicine, University Medical Centre Mannheim, 
      Mannheim, Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Borggrefe, Martin
AU  - Borggrefe M
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Papavassiliu, Theano
AU  - Papavassiliu T
AD  - 1st Department of Medicine, University Medical Centre Mannheim, Mannheim, 
      Germany.
AD  - DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170724
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/complications/*diagnostic imaging/pathology
MH  - Death, Sudden, Cardiac/etiology
MH  - Female
MH  - Gadolinium/*administration & dosage
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Assessment/*methods
MH  - Survival Analysis
PMC - PMC5524944
COIS- The authors declare that they have no competing interests.
EDAT- 2017/07/26 06:00
MHDA- 2019/02/26 06:00
PMCR- 2017/07/24
CRDT- 2017/07/26 06:00
PHST- 2017/03/20 00:00 [received]
PHST- 2017/06/14 00:00 [accepted]
PHST- 2017/07/26 06:00 [entrez]
PHST- 2017/07/26 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2017/07/24 00:00 [pmc-release]
AID - 10.1038/s41598-017-06533-0 [pii]
AID - 6533 [pii]
AID - 10.1038/s41598-017-06533-0 [doi]
PST - epublish
SO  - Sci Rep. 2017 Jul 24;7(1):6336. doi: 10.1038/s41598-017-06533-0.