PMID- 28740282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 0022-1155 (Print)
IS  - 0975-8402 (Electronic)
IS  - 0022-1155 (Linking)
VI  - 54
IP  - 8
DP  - 2017 Jul
TI  - Effects of marine collagen peptides on glucose metabolism and insulin resistance 
      in type 2 diabetic rats.
PG  - 2260-2269
LID - 10.1007/s13197-017-2663-z [doi]
AB  - The present study was conducted to investigate the effects of marine collagen 
      peptides (MCPs) on glucose metabolism and insulin resistance using a rat model of 
      type 2 diabetes mellitus (T2DM). Forty T2DM obese Wistar rats were randomly 
      assigned to receive varying doses of MCPs or a vehicle control for 4 weeks. Blood 
      glucose and insulin levels, as well as oxidative stress and inflammation were 
      measured. The expression of glucose transporter type 4 (GLUT4) in skeletal 
      muscles and peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in livers of 
      T2DM rats was also measured. It was found that in the group of 9.0 g/kg/day MCPs 
      significantly improved glucose, insulin, and homeostatic model assessment-insulin 
      resistance, and increased the insulin sensitivity index (ISI). In addition, the 
      groups of 4.5 and 2.25 g/kg/day MCPs significantly improved liver steatosis. It 
      was also found that MCPs decreased expression of oxidative stress biomarkers and 
      inflammatory cytokines and adipocytokines in T2DM rats. In conclusion, medium and 
      high doses of MCPs (>/=4.5 g/kg/day) improved glucose metabolism and insulin 
      sensitivity in T2DM rats. These beneficial effects of MCPs may be mediated by 
      decreasing oxidative stress and inflammation and by up-regulating GLUT4, and 
      PPAR-alpha activity.
FAU - Zhu, CuiFeng
AU  - Zhu C
AD  - Department of Nutrition, ShenZhen Hospital of Southern Medical University, 
      Shenzhen City, Guangdong Province People's Republic of China. ISNI: 0000 0000 
      8877 7471. GRID: grid.284723.8
AD  - Department of Nutrition, Shenzhen HengSheng Affiliated Hospital, Southern Medical 
      University, Shenzhen City, Guangdong Province People's Republic of China. ISNI: 
      0000 0000 8877 7471. GRID: grid.284723.8
AD  - The State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, 
      Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong 
      People's Republic of China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Nutrition, Shenzhen HengSheng Affiliated Hospital, Southern Medical 
      University, Shenzhen City, Guangdong Province People's Republic of China. ISNI: 
      0000 0000 8877 7471. GRID: grid.284723.8
FAU - Mu, Bo
AU  - Mu B
AD  - Department of Nutrition, The Second People's Hospital of Yunnan Province, Kunming 
      City, Yunnan Province People's Republic of China. ISNI: 0000 0004 1798 611X. 
      GRID: grid.469876.2
FAU - Zhang, Fan
AU  - Zhang F
AD  - Department of Endocrinology, Peking University ShenZhen Hospital, Shenzhen City, 
      GuangDong Province People's Republic of China. GRID: grid.440601.7
FAU - Lai, NanNan
AU  - Lai N
AD  - Basic Medical Research Institute of ShanDong Academy of Medical Sciences, Jinan 
      City, ShanDong Province People's Republic of China.
FAU - Zhou, JianXin
AU  - Zhou J
AD  - Department of Nutrition, Shenzhen HengSheng Affiliated Hospital, Southern Medical 
      University, Shenzhen City, Guangdong Province People's Republic of China. ISNI: 
      0000 0000 8877 7471. GRID: grid.284723.8
FAU - Xu, AiMin
AU  - Xu A
AD  - The State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, 
      Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong 
      People's Republic of China.
FAU - Liu, JianGuo
AU  - Liu J
AD  - Department of Nutrition, ShenZhen Hospital of Southern Medical University, 
      Shenzhen City, Guangdong Province People's Republic of China. ISNI: 0000 0000 
      8877 7471. GRID: grid.284723.8
FAU - Li, Yong
AU  - Li Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing City, People's Republic of China. ISNI: 0000 0001 2256 9319. 
      GRID: grid.11135.37
LA  - eng
PT  - Journal Article
DEP - 20170614
PL  - India
TA  - J Food Sci Technol
JT  - Journal of food science and technology
JID - 0056471
PMC - PMC5502017
OTO - NOTNLM
OT  - Adipocytokine
OT  - Inflammatory cytokines
OT  - Insulin resistance
OT  - Marine collagen peptide
OT  - Oxidative stress
COIS- The authors have no potential conflicts of interest relevant to this article.
EDAT- 2017/07/26 06:00
MHDA- 2017/07/26 06:01
PMCR- 2018/07/01
CRDT- 2017/07/26 06:00
PHST- 2017/04/19 00:00 [revised]
PHST- 2017/04/26 00:00 [accepted]
PHST- 2017/07/26 06:00 [entrez]
PHST- 2017/07/26 06:00 [pubmed]
PHST- 2017/07/26 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - 2663 [pii]
AID - 10.1007/s13197-017-2663-z [doi]
PST - ppublish
SO  - J Food Sci Technol. 2017 Jul;54(8):2260-2269. doi: 10.1007/s13197-017-2663-z. 
      Epub 2017 Jun 14.