PMID- 28743091
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20181202
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 158
DP  - 2017 Oct 1
TI  - Performance comparison of two herbal and industrial medicines using nanoparticles 
      with a starch/cellulose shell and alginate core for drug delivery: In vitro 
      studies.
PG  - 556-561
LID - S0927-7765(17)30430-7 [pii]
LID - 10.1016/j.colsurfb.2017.07.018 [doi]
AB  - In this study, the performance of two kinds of industrial and herbal drugs 
      encapsulated in nanoparticles with a shell of starch and cellulose and an 
      alginate core were examined as a new technique for nanoparticle drug delivery. 
      The test method involved creating a suspension of starch and alginate, which was 
      then dried, mixed with cellulose, and heated to form core-shell nanoparticles. 
      The industrial drug calcitonin and an extract of the herb Amaranthus retroflexcus 
      L. were added separately and in combination to the nanoparticles, and the 
      performance of each configuration was evaluated. Variables like shape, size of 
      nanoparticle, and pH were examined for their effect in vitro. Response surface 
      methodology (RSM) was employed for optimization of parameters. The properties of 
      the nanoparticles were studied by scanning electron microscopy (SEM) and 
      Ultraviolet-visible spectroscopy (UV-vis). The most optimal conditions for 
      formation of the smallest nanoparticles were found to be pH 4 with a 
      concentration of 0.15g starch, 0.04g alginate, and 0.01g cellulose, which 
      resulted in a spherical nanoparticle size of 25.6-68.7nm. This novel method for 
      helping bone regeneration offers a potentially major advance in the medical 
      treatment of osteoporosis. The results of optimization indicated that the most 
      optimal conditions of the tests were performed at pH 4, CA=0.04, CS=0.21, and 
      CC=0.01. In acidic pH the size of nanoparticles was less than 100nm.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Esmaeili, Akbar
AU  - Esmaeili A
AD  - Department of Chemical Engineering, North Tehran Branch, Islamic Azad University, 
      P.O. Box 19585/936, Tehran, Iran. Electronic address: akbaresmaeili@yahoo.com.
FAU - Behzadi, Sahar
AU  - Behzadi S
AD  - Department of Chemical Engineering, North Tehran Branch, Islamic Azad University, 
      P.O. Box 19585/936, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170718
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Alginates)
RN  - 0 (Drug Carriers)
RN  - 0 (Hexuronic Acids)
RN  - 8A5D83Q4RW (Glucuronic Acid)
RN  - 9004-34-6 (Cellulose)
RN  - 9005-25-8 (Starch)
SB  - IM
MH  - Alginates/*chemistry
MH  - Cellulose/*chemistry
MH  - Drug Carriers/*chemistry
MH  - Drug Delivery Systems/methods
MH  - Glucuronic Acid/chemistry
MH  - Hexuronic Acids/chemistry
MH  - Nanoparticles/*chemistry
MH  - Starch/*chemistry
OTO - NOTNLM
OT  - Alginate
OT  - Amaranthus retroflexcus
OT  - Calcitonin
OT  - Drug delivery
OT  - Nanoparticles
OT  - RSM
EDAT- 2017/07/26 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/04/19 00:00 [received]
PHST- 2017/06/06 00:00 [revised]
PHST- 2017/07/05 00:00 [accepted]
PHST- 2017/07/26 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/07/26 06:00 [entrez]
AID - S0927-7765(17)30430-7 [pii]
AID - 10.1016/j.colsurfb.2017.07.018 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2017 Oct 1;158:556-561. doi: 
      10.1016/j.colsurfb.2017.07.018. Epub 2017 Jul 18.