PMID- 28744117
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20181113
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Print)
IS  - 1176-9106 (Linking)
VI  - 12
DP  - 2017
TI  - Alteration of the irisin-brain-derived neurotrophic factor axis contributes to 
      disturbance of mood in COPD patients.
PG  - 2023-2033
LID - 10.2147/COPD.S135701 [doi]
AB  - COPD is accompanied by limited physical activity, worse quality of life, and 
      increased prevalence of depression. A possible link between COPD and depression 
      may be irisin, a myokine, expression of which in the skeletal muscle and brain 
      positively correlates with physical activity. Irisin enhances the synthesis of 
      brain-derived neurotrophic factor (BDNF), a neurotrophin involved in 
      reward-related processes. Thus, we hypothesized that mood disturbances 
      accompanying COPD are reflected by the changes in the irisin-BDNF axis. Case 
      history, routine laboratory parameters, serum irisin and BDNF levels, pulmonary 
      function, and disease-specific quality of life, measured by St George's 
      Respiratory Questionnaire (SGRQ), were determined in a cohort of COPD patients 
      (n=74). Simple and then multiple linear regression were used to evaluate the 
      data. We found that mood disturbances are associated with lower serum irisin 
      levels (SGRQ's Impacts score and reciprocal of irisin showed a strong positive 
      association; beta: 419.97; 95% confidence interval [CI]: 204.31, 635.63; P<0.001). 
      This association was even stronger among patients in the lower 50% of BDNF levels 
      (beta: 434.11; 95% CI: 166.17, 702.05; P=0.002), while it became weaker for patients 
      in the higher 50% of BDNF concentrations (beta: 373.49; 95% CI: -74.91, 821.88; 
      P=0.1). These results suggest that irisin exerts beneficial effect on mood in 
      COPD patients, possibly by inducing the expression of BDNF in brain areas 
      associated with reward-related processes involved in by depression. Future 
      interventional studies targeting the irisin-BDNF axis (eg, endurance training) 
      are needed to further support this notion.
FAU - Papp, Csaba
AU  - Papp C
AD  - Department of Health Systems Management and Quality Management for Health Care, 
      Faculty of Public Health.
FAU - Pak, Krisztian
AU  - Pak K
AD  - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine.
FAU - Erdei, Tamas
AU  - Erdei T
AD  - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine.
FAU - Juhasz, Bela
AU  - Juhasz B
AD  - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine.
FAU - Seres, Ildiko
AU  - Seres I
AD  - Department of Internal Medicine, Faculty of Medicine, University of Debrecen.
FAU - Szentpeteri, Anita
AU  - Szentpeteri A
AD  - Department of Internal Medicine, Faculty of Medicine, University of Debrecen.
FAU - Kardos, Laszlo
AU  - Kardos L
AD  - Department of Clinical Pharmacology, Infectious Diseases and Allergology, Kenezy 
      Gyula Teaching County Hospital and Outpatient Clinic.
FAU - Szilasi, Maria
AU  - Szilasi M
AD  - Department of Pulmonology, Faculty of Medicine, University of Debrecen, Debrecen, 
      Hungary.
FAU - Gesztelyi, Rudolf
AU  - Gesztelyi R
AD  - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine.
FAU - Zsuga, Judit
AU  - Zsuga J
AD  - Department of Health Systems Management and Quality Management for Health Care, 
      Faculty of Public Health.
LA  - eng
PT  - Journal Article
DEP - 20170707
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - *Affect
MH  - Aged
MH  - Brain/*metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Depression/*blood/diagnosis/physiopathology/psychology
MH  - Female
MH  - Fibronectins/*blood
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Linear Models
MH  - Lung/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Pulmonary Disease, Chronic 
      Obstructive/*blood/diagnosis/physiopathology/psychology
MH  - Quality of Life
MH  - Respiratory Function Tests
MH  - Reward
MH  - Risk Factors
MH  - Signal Transduction
MH  - Surveys and Questionnaires
PMC - PMC5511021
OTO - NOTNLM
OT  - BDNF
OT  - SGRQ
OT  - irisin
OT  - whole-body plethysmography
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/07/27 06:00
MHDA- 2018/05/01 06:00
PMCR- 2017/07/07
CRDT- 2017/07/27 06:00
PHST- 2017/07/27 06:00 [entrez]
PHST- 2017/07/27 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2017/07/07 00:00 [pmc-release]
AID - copd-12-2023 [pii]
AID - 10.2147/COPD.S135701 [doi]
PST - epublish
SO  - Int J Chron Obstruct Pulmon Dis. 2017 Jul 7;12:2023-2033. doi: 
      10.2147/COPD.S135701. eCollection 2017.