PMID- 28744368
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2045-9912 (Print)
IS  - 2045-9912 (Electronic)
IS  - 2045-9912 (Linking)
VI  - 7
IP  - 2
DP  - 2017 Apr-Jun
TI  - Subacute normobaric oxygen and hyperbaric oxygen therapy in drowning, reversal of 
      brain volume loss: a case report.
PG  - 144-149
LID - 10.4103/2045-9912.208521 [doi]
AB  - A 2-year-old girl experienced cardiac arrest after cold water drowning. Magnetic 
      resonance imaging (MRI) showed deep gray matter injury on day 4 and cerebral 
      atrophy with gray and white matter loss on day 32. Patient had no speech, gait, 
      or responsiveness to commands on day 48 at hospital discharge. She received 
      normobaric 100% oxygen treatment (2 L/minute for 45 minutes by nasal cannula, 
      twice/day) since day 56 and then hyperbaric oxygen treatment (HBOT) at 1.3 
      atmosphere absolute (131.7 kPa) air/45 minutes, 5 days/week for 40 sessions since 
      day 79; visually apparent and/or physical examination-documented neurological 
      improvement occurred upon initiating each therapy. After HBOT, the patient had 
      normal speech and cognition, assisted gait, residual fine motor and temperament 
      deficits. MRI at 5 months after injury and 27 days after HBOT showed 
      near-normalization of ventricles and reversal of atrophy. Subacute normobaric 
      oxygen and HBOT were able to restore drowning-induced cortical gray matter and 
      white matter loss, as documented by sequential MRI, and simultaneous neurological 
      function, as documented by video and physical examinations.
FAU - Harch, Paul G
AU  - Harch PG
AUID- ORCID: 0000-0001-7329-0078
AD  - Department of Medicine, Section of Emergency Medicine, University Medical Center, 
      Louisiana State University School of Medicine, New Orleans, LA, USA.
FAU - Fogarty, Edward F
AU  - Fogarty EF
AD  - Department of Radiology, University of North Dakota School of Medicine, Bismarck, 
      ND, USA.
LA  - eng
PT  - Case Reports
DEP - 20170630
PL  - Australia
TA  - Med Gas Res
JT  - Medical gas research
JID - 101564536
PMC - PMC5510296
OTO - NOTNLM
OT  - brain volume
OT  - drowning
OT  - gray matter
OT  - hyperbaric oxygen
OT  - magnetic resonance imaging
OT  - normobaric oxygen
OT  - white matter
COIS- Conflicts of interest PGH is co-owner of Harch Hyperbarics, Inc., a corporation 
      that performs hyperbaric medicine consulting and expert witness 
      testimony/opinions. He is also on the board of directors of the International 
      Hyperbaric Medical Association (IHMA), a non-profit corporation. He derives no 
      income from the IHMA. EFF is president of the International Hyperbaric Medical 
      Foundation (IHMF), a non-profit corporation that promotes education, research, 
      and teaching in hyperbaric medicine. He derives no income from the IHMF.
EDAT- 2017/07/27 06:00
MHDA- 2017/07/27 06:01
PMCR- 2017/06/30
CRDT- 2017/07/27 06:00
PHST- 2017/07/27 06:00 [entrez]
PHST- 2017/07/27 06:00 [pubmed]
PHST- 2017/07/27 06:01 [medline]
PHST- 2017/06/30 00:00 [pmc-release]
AID - MGR-7-144 [pii]
AID - 10.4103/2045-9912.208521 [doi]
PST - epublish
SO  - Med Gas Res. 2017 Jun 30;7(2):144-149. doi: 10.4103/2045-9912.208521. eCollection 
      2017 Apr-Jun.