PMID- 28744416 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 9 IP - 6 DP - 2017 Jun 19 TI - Immune Reconstitution Inflammatory Syndrome Associated Thrombocytopenia in a Patient with Human Immunodeficiency Virus Infection: A Rare Hematological Manifestation. PG - e1369 LID - 10.7759/cureus.1369 [doi] LID - e1369 AB - Human immunodeficiency virus (HIV) associated thrombocytopenia was commonly encountered in the era prior to the advent of antiretroviral therapy (ART). With the widespread use of ART, its incidence has significantly declined. Immune reconstitution inflammatory syndrome (IRIS) is an immune dysregulation phenomenon that reveals itself clinically as paradoxical deterioration after the commencement of ART in HIV infected patients. It has a wide variety of clinical manifestations. However, hematologic involvement is rare. Here, we present a very rare case of IRIS associated thrombocytopenia. With this case we intend to create mindfulness of the possibility of IRIS being one of the explanations for thrombocytopenia. FAU - Asif, Talal AU - Asif T AD - Department of Internal Medicine, University of Missouri Kansas City (UMKC). FAU - Hasan, Badar AU - Hasan B AD - Department of Internal Medicine, University of Missouri Kansas City (UMKC). FAU - Ukani, Rehman AU - Ukani R AD - Department of Internal Medicine, University of Missouri Kansas City (UMKC). FAU - Pauly, Rebecca R AU - Pauly RR AD - Department of Internal Medicine, University of Missouri Kansas City (UMKC). LA - eng PT - Case Reports DEP - 20170619 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC5519318 OTO - NOTNLM OT - iris OT - iris associated thrombocytopenia OT - thrombocytopenia in hiv COIS- The authors have declared that no competing interests exist. EDAT- 2017/07/27 06:00 MHDA- 2017/07/27 06:01 PMCR- 2017/06/19 CRDT- 2017/07/27 06:00 PHST- 2017/07/27 06:00 [entrez] PHST- 2017/07/27 06:00 [pubmed] PHST- 2017/07/27 06:01 [medline] PHST- 2017/06/19 00:00 [pmc-release] AID - 10.7759/cureus.1369 [doi] PST - epublish SO - Cureus. 2017 Jun 19;9(6):e1369. doi: 10.7759/cureus.1369.