PMID- 28745034
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20211204
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 19
IP  - 2
DP  - 2018 Mar
TI  - Transglutaminase antibodies and celiac disease in children with type 1 diabetes 
      and in their family members.
PG  - 305-313
LID - 10.1111/pedi.12563 [doi]
AB  - OBJECTIVES: We set out to determine the prevalence of tissue transglutaminase 
      antibodies (anti-tTG) and celiac disease (CD) in children with newly diagnosed 
      type 1 diabetes (T1D) and their first-degree relatives (FDR). The hypothesis was 
      that the individuals with both diabetes and CD form a distinct subgroup in terms 
      of human leukocyte antigen (HLA) class II genetics, islet autoantibodies, and 
      clinical characteristics at diabetes diagnosis. SUBJECTS AND METHODS: This 
      population-based observational study included 745 index children with T1D and 
      their 2692 FDR from the Finnish Pediatric Diabetes Register. CD was ascertained 
      by registers, patient records, and screening anti-tTG positive individuals for 
      further testing. RESULTS: Among the index children, 4.8% had anti-tTG at diabetes 
      diagnosis, and at the end of the study 3.2% had CD. Among the relatives, 2.9% had 
      anti-tTG (4.8% mothers, 2.4% fathers, and 2.1% siblings), and 2.5% had CD (4.6% 
      mothers, 2.1% fathers, and 1.4% siblings). Anti-tTG and CD associated with the 
      HLA DR3-DQ2 haplotype. The usual female predominance of CD patients was observed 
      in relatives (70%) but not among index children (46%). The index children with 
      both diseases had a lower number of detectable islet autoantibodies than those 
      with diabetes alone. CONCLUSIONS: The children with double diagnosis differed 
      from those with diabetes alone in HLA genetics, humoral islet autoimmunity 
      directed against fewer antigens, and in the lack of usual female preponderance 
      among CD patients. Compared with 61% of the anti-tTG positive relatives, only 36% 
      of anti-tTG positive index children developed CD implicating transient anti-tTG 
      positivity at diagnosis of T1D.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Parkkola, Anna
AU  - Parkkola A
AD  - Scientific Laboratory, Children's Hospital, University of Helsinki and Helsinki 
      University Hospital, Helsinki, Finland.
AD  - Folkhalsan Research Center, Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
FAU - Harkonen, Taina
AU  - Harkonen T
AD  - Scientific Laboratory, Children's Hospital, University of Helsinki and Helsinki 
      University Hospital, Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
FAU - Ryhanen, Samppa J
AU  - Ryhanen SJ
AD  - Scientific Laboratory, Children's Hospital, University of Helsinki and Helsinki 
      University Hospital, Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
FAU - Uibo, Raivo
AU  - Uibo R
AD  - Department of Immunology, Institute of Biomedicine and Translational Medicine, 
      University of Tartu, Tartu, Estonia.
FAU - Ilonen, Jorma
AU  - Ilonen J
AUID- ORCID: 0000-0002-9973-2062
AD  - Immunogenetics Laboratory, University of Turku, Turku, Finland.
FAU - Knip, Mikael
AU  - Knip M
AUID- ORCID: 0000-0003-0474-0033
AD  - Scientific Laboratory, Children's Hospital, University of Helsinki and Helsinki 
      University Hospital, Helsinki, Finland.
AD  - Folkhalsan Research Center, Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
AD  - Tampere Center for Child Health Research, Tampere University Hospital, Tampere, 
      Finland.
CN  - Finnish Pediatric Diabetes Register
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20170726
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (islet cell antibody)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Autoantibodies/*analysis
MH  - *Autoimmunity
MH  - Biomarkers/blood
MH  - Celiac Disease/complications/epidemiology/genetics/*immunology
MH  - Child
MH  - Diabetes Mellitus, Type 1/blood/complications/genetics/*immunology
MH  - *Family Health
MH  - Female
MH  - Finland/epidemiology
MH  - GTP-Binding Proteins/*antagonists & inhibitors/metabolism
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/chemistry/genetics
MH  - HLA-DR3 Antigen/chemistry/genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Medical Records
MH  - Prevalence
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - Registries
MH  - Sex Factors
MH  - Transglutaminases/*antagonists & inhibitors/metabolism
OTO - NOTNLM
OT  - HLA
OT  - endomysial antibodies
OT  - islet autoantibodies
OT  - pediatric
EDAT- 2017/07/27 06:00
MHDA- 2018/11/06 06:00
CRDT- 2017/07/27 06:00
PHST- 2017/03/16 00:00 [received]
PHST- 2017/06/19 00:00 [revised]
PHST- 2017/06/23 00:00 [accepted]
PHST- 2017/07/27 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2017/07/27 06:00 [entrez]
AID - 10.1111/pedi.12563 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2018 Mar;19(2):305-313. doi: 10.1111/pedi.12563. Epub 2017 Jul 
      26.