PMID- 2874566
OWN - NLM
STAT- MEDLINE
DCOM- 19860917
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 24
IP  - 6
DP  - 1986 Jun
TI  - Discriminative profile of MDMA.
PG  - 1533-7
AB  - Groups of rats were trained to discriminate the stimulus properties of 
      dopaminergically and/or serotonergically active drugs, viz., apomorphine, 
      fenfluramine, tetrahydro-beta-carboline (THBC) and l-cathinone. Once trained, 
      these animals were given several doses of drugs used in training and 
      dose-response relationships and ED50 values were generated. Subsequently, each 
      group of trained rats was administered various doses of 
      3,4-methylenedioxymethamphetamine (MDMA) to test generalization of the 
      interoceptive cue of the drug used for training to MDMA. Rats trained to 
      fenfluramine, THBC, and l-cathinone were observed to discriminate MDMA in a 
      manner similar to the drug state to which they had been trained. Analysis of 
      dose-response curves suggested that MDMA may be acting both as an indirect 
      dopaminergic agonist and as a serotonergic receptor agonist. This duality of 
      effect of MDMA has been evidenced by other studies and may account for its 
      present abuse potential.
FAU - Schechter, M D
AU  - Schechter MD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, Serotonin)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - N21FAR7B4S (Apomorphine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Discrimination Learning/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fenfluramine/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Receptors, Dopamine/drug effects
MH  - Receptors, Serotonin/drug effects
EDAT- 1986/06/01 00:00
MHDA- 1986/06/01 00:01
CRDT- 1986/06/01 00:00
PHST- 1986/06/01 00:00 [pubmed]
PHST- 1986/06/01 00:01 [medline]
PHST- 1986/06/01 00:00 [entrez]
AID - 0091-3057(86)90480-6 [pii]
AID - 10.1016/0091-3057(86)90480-6 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1986 Jun;24(6):1533-7. doi: 
      10.1016/0091-3057(86)90480-6.