PMID- 28747014
OWN - NLM
STAT- MEDLINE
DCOM- 20180420
LR  - 20180420
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 93
DP  - 2017 Sep
TI  - MicroRNAs and adipocytokines: Promising biomarkers for pharmacological targets in 
      diabetes mellitus and its complications.
PG  - 1326-1336
LID - S0753-3322(17)32041-3 [pii]
LID - 10.1016/j.biopha.2017.07.059 [doi]
AB  - Nowadays, diabetes mellitus (DM) along with its complications is considered as a 
      fundamental problem in both developing and industrial countries, and is causing 
      millions of people to suffer worldwide. Currently, diabetes mellitus is diagnosed 
      traditionally or classically in the world by measuring fasting blood glucose and 
      conducting oral glucose tolerance test. New alternatives are required for the 
      treatment of diabetes mellitus, especially type 2 diabetes mellitus (T2DM), at 
      its early levels due to the ineffective control of its development in patients. 
      In recent years, by further identifying of molecular agents such as microRNAs 
      (miRNAs), studies have focused on miRNAs in diabetes as well as in other 
      diseases. These small non-coding RNA molecules have a significant role in the 
      regulation of insulin gene expression and also, obesity problems. White adipose 
      tissue, as an important tissue in obese subjects, is directly related to type 2 
      diabetes and its complications via synthesis of adipokines. Prevention and 
      treatment of obesity should be noted since childhood. Our aim in this review is 
      to briefly provide a new glance at types of potential biomarkers, which can be 
      used as pharmacological targets for prevention and treatment of prediabetic 
      subjects, and patients with T2DM.
CI  - Copyright (c) 2017. Published by Elsevier Masson SAS.
FAU - Ashoori, Mohamad Reza
AU  - Ashoori MR
AD  - Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz 
      University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Rahmati-Yamchi, Mohammad
AU  - Rahmati-Yamchi M
AD  - Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Ostadrahimi, Alireza
AU  - Ostadrahimi A
AD  - Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Fekri Aval, Sedigheh
AU  - Fekri Aval S
AD  - Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Zarghami, Nosratollah
AU  - Zarghami N
AD  - Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz 
      University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Tabriz 
      University of Medical Sciences, Tabriz, Iran; Department of Medical 
      Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical 
      Sciences, Tabriz, Iran. Electronic address: zarghami@tbzmed.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170723
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adipokines/*metabolism
MH  - Biomarkers/*metabolism
MH  - Blood Glucose/genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Expression/genetics
MH  - Humans
MH  - Insulin/genetics
MH  - MicroRNAs/*genetics
MH  - Prediabetic State/genetics
OTO - NOTNLM
OT  - Adipocytokine
OT  - MicroRNA
OT  - Obesity
OT  - Pharmacological target
EDAT- 2017/07/28 06:00
MHDA- 2018/04/21 06:00
CRDT- 2017/07/28 06:00
PHST- 2017/04/27 00:00 [received]
PHST- 2017/07/08 00:00 [revised]
PHST- 2017/07/11 00:00 [accepted]
PHST- 2017/07/28 06:00 [pubmed]
PHST- 2018/04/21 06:00 [medline]
PHST- 2017/07/28 06:00 [entrez]
AID - S0753-3322(17)32041-3 [pii]
AID - 10.1016/j.biopha.2017.07.059 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 Sep;93:1326-1336. doi: 10.1016/j.biopha.2017.07.059. 
      Epub 2017 Jul 23.