PMID- 28748852
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20220316
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 130
IP  - 15
DP  - 2017 Aug 5
TI  - Pretreated Glehnia littoralis Extract Prevents Neuronal Death Following Transient 
      Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and 
      Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu 
      Ammonis 1 Area.
PG  - 1796-1803
LID - 10.4103/0366-6999.211554 [doi]
AB  - BACKGROUND: Glehnia littoralis, as a traditional herbal medicine to heal various 
      health ailments in East Asia, displays various therapeutic properties including 
      antioxidant effects. However, neuroprotective effects of G. littoralis against 
      cerebral ischemic insults have not yet been addressed. Therefore, in this study, 
      we first examined its neuroprotective effects in the hippocampus using a gerbil 
      model of transient global cerebral ischemia (TGCI). METHODS: Gerbils were 
      subjected to TGCI for 5 min. G. littoralis extract (GLE; 100 and 200 mg/kg) was 
      administrated orally once daily for 7 days before ischemic surgery. 
      Neuroprotection was examined by neuronal nuclear antigen immunohistochemistry and 
      Fluoro-Jade B histofluorescence staining. Gliosis was observed by 
      immunohistochemistry for glial fibrillary acidic protein and ionized 
      calcium-binding adapter molecule 1. For neuroprotective mechanisms, 
      immunohistochemistry for superoxide dismutase (SOD) 1 and brain-derived 
      neurotrophic factor (BDNF) was done. RESULTS: Pretreatment with 200 mg/kg of GLE 
      protected pyramidal neurons in the cornu ammonis 1 (CA1) area from ischemic 
      insult area (F = 29.770, P < 0.05) and significantly inhibited activations of 
      astrocytes (F = 22.959, P < 0.05) and microglia (F = 44.135, P < 0.05) in the 
      ischemic CA1 area. In addition, pretreatment with GLE significantly increased 
      expressions of SOD1 (F = 28.561, P < 0.05) and BDNF (F = 55.298, P < 0.05) in CA1 
      pyramidal neurons of the sham- and ischemia-operated groups. CONCLUSIONS: Our 
      findings indicate that pretreatment with GLE can protect neurons from ischemic 
      insults, and we suggest that its neuroprotective mechanism may be closely 
      associated with increases of SOD1 and BDNF expressions as well as attenuation of 
      glial activation.
FAU - Park, Joon Ha
AU  - Park JH
AD  - Department of Biomedical Science, Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon 24252, Korea.
FAU - Lee, Tae-Kyeong
AU  - Lee TK
AD  - Department of Neurobiology, School of Medicine, Kangwon National University, 
      Chuncheon 24341, Korea.
FAU - Yan, Bing-Chun
AU  - Yan BC
AD  - Department of Traditional Chinese and Western Medicine, Jiangsu Key Laboratory of 
      Integrated Traditional Chinese and Western Medicine for Prevention and Treatment 
      of Senile Diseases, Yangzhou, Jiangsu 225001, China.
FAU - Shin, Bich-Na
AU  - Shin BN
AD  - Department of Physiology, College of Medicine, Hallym University, Chuncheon 
      24252, Korea.
FAU - Ahn, Ji Hyeon
AU  - Ahn JH
AD  - Department of Biomedical Science, Research Institute of Bioscience and 
      Biotechnology, Hallym University, Chuncheon 24252, Korea.
FAU - Kim, In Hye
AU  - Kim IH
AD  - Department of Neurobiology, School of Medicine, Kangwon National University, 
      Chuncheon 24341, Korea.
FAU - Cho, Jeong Hwi
AU  - Cho JH
AD  - Department of Neurobiology, School of Medicine, Kangwon National University, 
      Chuncheon 24341, Korea.
FAU - Lee, Jae-Chul
AU  - Lee JC
AD  - Department of Neurobiology, School of Medicine, Kangwon National University, 
      Chuncheon 24341, Korea.
FAU - Hwang, In Koo
AU  - Hwang IK
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul 
      08826, Korea.
FAU - Kim, Jong Dai
AU  - Kim JD
AD  - Division of Food Biotechnology, School of Biotechnology, Kangwon National 
      University, Chuncheon, 24341, Korea.
FAU - Hong, Seongkweon
AU  - Hong S
AD  - Department of Surgery, School of Medicine, Kangwon National University, Chuncheon 
      24341, Korea.
FAU - Lee, Young Joo
AU  - Lee YJ
AD  - Department of Emergency Medicine, Seoul Hospital, College of Medicine, 
      Sooncheonhyang University, Seoul 04401, Korea.
FAU - Won, Moo-Ho
AU  - Won MH
AD  - Department of Neurobiology, School of Medicine, Kangwon National University, 
      Chuncheon 24341, Korea.
FAU - Kang, Il Jun
AU  - Kang IJ
AD  - Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, 
      Korea.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Plant Extracts)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - CA1 Region, Hippocampal/*drug effects/*metabolism
MH  - Calcium-Binding Proteins/genetics/metabolism
MH  - Gerbillinae
MH  - Glial Fibrillary Acidic Protein/genetics/metabolism
MH  - Gliosis/metabolism
MH  - Immunohistochemistry
MH  - Plant Extracts/*pharmacology
MH  - Superoxide Dismutase/genetics/*metabolism
PMC - PMC5547831
COIS- There are no conflicts of interest.
EDAT- 2017/07/28 06:00
MHDA- 2018/04/18 06:00
PMCR- 2017/08/05
CRDT- 2017/07/28 06:00
PHST- 2017/07/28 06:00 [entrez]
PHST- 2017/07/28 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2017/08/05 00:00 [pmc-release]
AID - ChinMedJ_2017_130_15_1796_211554 [pii]
AID - CMJ-130-1796 [pii]
AID - 10.4103/0366-6999.211554 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2017 Aug 5;130(15):1796-1803. doi: 10.4103/0366-6999.211554.