PMID- 28749085
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20181202
IS  - 1476-4431 (Electronic)
IS  - 1476-4431 (Linking)
VI  - 27
IP  - 5
DP  - 2017 Sep
TI  - A pilot study evaluating the prognostic utility of platelet indices in dogs with 
      septic peritonitis.
PG  - 569-578
LID - 10.1111/vec.12628 [doi]
AB  - OBJECTIVE: To characterize platelet indices at time of diagnosis of septic 
      peritonitis in dogs and to assess the relationship between platelet parameter 
      data and survival to discharge in dogs treated surgically. DESIGN: Retrospective, 
      observational, descriptive pilot study from 2009 to 2014. SETTING: University 
      teaching hospital. ANIMALS: Forty-eight dogs diagnosed with septic peritonitis 
      were included in this study. Thirty-six dogs had surgical source control. Blood 
      samples from 46 healthy control dogs were used for reference interval (RI) 
      generation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Dogs with septic 
      peritonitis had significantly increased mean values for mean platelet volume 
      (MPV), plateletcrit (PCT), and platelet distribution width (PDW) with increased 
      proportions of dogs having values above the RI compared to healthy dogs. A 
      significantly increased proportion of dogs with septic peritonitis had platelet 
      counts above (12.5%) and below (8.3%) the RI, with no significant difference in 
      mean platelet count compared to healthy dogs. No significant differences in the 
      mean platelet count, MPV, PCT, or PDW were found between survivors and 
      nonsurvivors in dogs with surgical source control; however, dogs with MPV values 
      above the RI had significantly increased mortality compared to dogs within the RI 
      (P = 0.025). Values outside the RI for other platelet parameters were not 
      associated with significant differences in mortality. CONCLUSIONS: Dogs with 
      septic peritonitis have increased frequency of thrombocytosis and 
      thrombocytopenia with increased MPV, PCT, and PDW. An increased MPV may be a 
      useful indicator of increased risk of mortality in dogs treated surgically.
CI  - (c) Veterinary Emergency and Critical Care Society 2017.
FAU - Llewellyn, Efa A
AU  - Llewellyn EA
AUID- ORCID: 0000-0001-9581-9673
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, 
      University of Minnesota, St Paul, MN, 55108.
FAU - Todd, Jeffrey M
AU  - Todd JM
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, 
      University of Minnesota, St Paul, MN, 55108.
FAU - Sharkey, Leslie C
AU  - Sharkey LC
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, 
      University of Minnesota, St Paul, MN, 55108.
FAU - Rendahl, Aaron
AU  - Rendahl A
AD  - School of Statistics, University of Minnesota, St Paul, MN, 55108.
LA  - eng
PT  - Journal Article
DEP - 20170727
PL  - United States
TA  - J Vet Emerg Crit Care (San Antonio)
JT  - Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
JID - 101152804
SB  - IM
MH  - Animals
MH  - Blood Platelet Disorders/blood/*veterinary
MH  - Dog Diseases/*blood
MH  - Dogs
MH  - Mean Platelet Volume
MH  - Peritonitis/blood/*veterinary
MH  - Pilot Projects
MH  - Platelet Count/*veterinary
MH  - Prognosis
MH  - Reference Values
MH  - Retrospective Studies
MH  - Sepsis/blood/*veterinary
MH  - Thrombocytopenia
OTO - NOTNLM
OT  - macroplatelets
OT  - mean platelet volume
OT  - platelet distribution width
OT  - plateletcrit
OT  - sepsis
OT  - systemic inflammatory response syndrome
EDAT- 2017/07/28 06:00
MHDA- 2018/03/10 06:00
CRDT- 2017/07/28 06:00
PHST- 2015/07/16 00:00 [received]
PHST- 2015/09/22 00:00 [revised]
PHST- 2015/11/08 00:00 [accepted]
PHST- 2017/07/28 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/07/28 06:00 [entrez]
AID - 10.1111/vec.12628 [doi]
PST - ppublish
SO  - J Vet Emerg Crit Care (San Antonio). 2017 Sep;27(5):569-578. doi: 
      10.1111/vec.12628. Epub 2017 Jul 27.