PMID- 28749427
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20230928
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 22
IP  - 8
DP  - 2017 Jul 27
TI  - Advanced Growth Factor Delivery Systems in Wound Management and Skin 
      Regeneration.
LID - 10.3390/molecules22081259 [doi]
LID - 1259
AB  - Growth factors are endogenous signaling molecules that regulate cellular 
      responses required for wound healing processes such as migration, proliferation, 
      and differentiation. However, exogenous application of growth factors has limited 
      effectiveness in clinical settings due to their low in vivo stability, restricted 
      absorption through skin around wound lesions, elimination by exudation prior to 
      reaching the wound area, and other unwanted side effects. Sophisticated systems 
      to control the spatio-temporal delivery of growth factors are required for the 
      effective and safe use of growth factors as regenerative treatments in clinical 
      practice, such as biomaterial-based drug delivery systems (DDSs). The current 
      review describes the roles of growth factors in wound healing, their clinical 
      applications for the treatment of chronic wounds, and advances in growth 
      factor-loaded DDSs for enhanced wound healing, focusing on micro- and 
      nano-particulate systems, scaffolds, hydrogels, and other miscellaneous systems.
FAU - Park, Jin Woo
AU  - Park JW
AD  - Department of Pharmacy, College of Pharmacy and Natural Medicine Research 
      Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Korea. 
      jwpark@mokpo.ac.kr.
FAU - Hwang, Seung Rim
AU  - Hwang SR
AD  - Department of Pharmacy, College of Pharmacy, Chosun University, Dong-gu, Gwangju 
      61452, Korea. srhwang@chosun.ac.kr.
FAU - Yoon, In-Soo
AU  - Yoon IS
AD  - College of Pharmacy, Pusan National University, Geumjeong-gu, Busan 46241, Korea. 
      insoo.yoon@pusan.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170727
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Biocompatible Materials)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*administration & 
      dosage/*pharmacology
MH  - Regeneration/*drug effects
MH  - Skin/drug effects/*pathology
MH  - Wound Healing/*drug effects
PMC - PMC6152378
OTO - NOTNLM
OT  - chronic wound
OT  - drug delivery system
OT  - growth factor
OT  - wound healing
COIS- The authors declare no conflicts of interest.
EDAT- 2017/07/28 06:00
MHDA- 2018/04/17 06:00
PMCR- 2017/07/27
CRDT- 2017/07/28 06:00
PHST- 2017/07/04 00:00 [received]
PHST- 2017/07/21 00:00 [revised]
PHST- 2017/07/25 00:00 [accepted]
PHST- 2017/07/28 06:00 [entrez]
PHST- 2017/07/28 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
PHST- 2017/07/27 00:00 [pmc-release]
AID - molecules22081259 [pii]
AID - molecules-22-01259 [pii]
AID - 10.3390/molecules22081259 [doi]
PST - epublish
SO  - Molecules. 2017 Jul 27;22(8):1259. doi: 10.3390/molecules22081259.