PMID- 28749757
OWN - NLM
STAT- MEDLINE
DCOM- 20171018
LR  - 20231112
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 3
DP  - 2017 Sep
TI  - Paracoccidioidomycosis: Epidemiological and Clinical Aspects in 546 Cases Studied 
      in the State of Espirito Santo, Brazil.
PG  - 836-844
LID - 10.4269/ajtmh.16-0790 [doi]
AB  - Paracoccidioidomycosis (PCM) is an endemic disease in the southeast region of 
      Brazil, which includes the state of Espirito Santo (ES). This historic case 
      series analyses 546 patients treated in this state from 1978 to 2012. Patients 
      aged from 7 to 83 years, 509 males and 37 females, yielding a ratio of 13.7:1. 
      Most of the patients (81.4%) originated from rural areas in ES, 71.0% being 
      farmers. A higher concentration of cases was observed in municipalities located 
      along the western range of the state. Sixty patients (11.0%) had an 
      acute/subacute form of the disease, 485 (88.9%) had a chronic form, and one had a 
      subclinical form. The most affected organs included the lungs, oropharyngeal 
      mucosa, lymph nodes, skin, and larynx. The diagnosis was confirmed by 
      histopathology in 252 (46.2%) cases, direct examination in 168 (30.7%), both 
      exams in 111 (20.3%) and serology in 15 (2.8%). Tuberculosis, acquired immune 
      deficiency syndrome, leishmaniasis, and intestinal parasites were the most 
      frequently associated infectious diseases. From 328 patients followed up, total 
      regression of the lesions was observed in 17.4%, partial regression in 77.4%, and 
      no regression in 17 (5.2%) cases. Regarding the number of cases in this series, 
      ES emerges as an important endemic area for PCM in Brazil.
FAU - Pecanha, Paulo Mendes
AU  - Pecanha PM
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Batista Ferreira, Mayara Elisa
AU  - Batista Ferreira ME
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Massaroni Pecanha, Maria Angelica
AU  - Massaroni Pecanha MA
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Schmidt, Edilaine Brandao
AU  - Schmidt EB
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Lamas de Araujo, Mariceli
AU  - Lamas de Araujo M
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Zanotti, Raphael Lubiana
AU  - Zanotti RL
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Potratz, Felipe Fonseca
AU  - Potratz FF
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Delboni Nunes, Nilo Eduardo
AU  - Delboni Nunes NE
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Goncalves Ferreira, Carlos Urbano
AU  - Goncalves Ferreira CU
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Delmaestro, Delio
AU  - Delmaestro D
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
FAU - Falqueto, Aloisio
AU  - Falqueto A
AD  - Infectious Diseases and Dermatology Units of the Hospital Universitario Cassiano 
      Antonio Moraes, Universidade Federal do Espirito Santo, Vitoria, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170727
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging
MH  - Brazil/epidemiology
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioidomycosis/*epidemiology/*pathology
MH  - Young Adult
PMC - PMC5590575
EDAT- 2017/07/28 06:00
MHDA- 2017/10/19 06:00
PMCR- 2018/09/07
CRDT- 2017/07/28 06:00
PHST- 2017/07/28 06:00 [pubmed]
PHST- 2017/10/19 06:00 [medline]
PHST- 2017/07/28 06:00 [entrez]
PHST- 2018/09/07 00:00 [pmc-release]
AID - tpmd160790 [pii]
AID - 10.4269/ajtmh.16-0790 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Sep;97(3):836-844. doi: 10.4269/ajtmh.16-0790. Epub 2017 
      Jul 27.