PMID- 28750026 OWN - NLM STAT- MEDLINE DCOM- 20171004 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 12 IP - 7 DP - 2017 TI - Differences in biopsychosocial profiles of diabetes patients by level of glycaemic control and health-related quality of life: The Maastricht Study. PG - e0182053 LID - 10.1371/journal.pone.0182053 [doi] LID - e0182053 AB - AIMS: Tailored, patient-centred innovations are needed in the care for persons with type 2 diabetes mellitus (T2DM), in particular those with insufficient glycaemic control. Therefore, this study sought to assess their biopsychosocial characteristics and explore whether distinct biopsychosocial profiles exist within this subpopulation, which differ in health-related quality of life (HRQoL). METHODS: Cross-sectional study based on data from The Maastricht Study, a population-based cohort study focused on the aetiology, pathophysiology, complications, and comorbidities of T2DM. We analysed associations and clustering of glycaemic control and HRQoL with 38 independent variables (i.e. biopsychosocial characteristics) in different subgroups and using descriptive analyses, latent class analysis (LCA), and logistic regressions. RESULTS: Included were 840 persons with T2DM, mostly men (68.6%) and with a mean age of 62.6 (+/-7.7) years. Mean HbA1c was 7.1% (+/-3.2%); 308 patients (36.7%) had insufficient glycaemic control (HbA1c>7.0% [53 mmol/mol]). Compared to those with sufficient control, these patients had a significantly worse-off status on multiple biopsychosocial factors, including self-efficacy, income, education and several health-related characteristics. Two 'latent classes' were identified in the insufficient glycaemic control subgroup: with low respectively high HRQoL. Of the two, the low HRQoL class comprised about one-fourth of patients and had a significantly worse biopsychosocial profile. CONCLUSIONS: Insufficient glycaemic control, particularly in combination with low HRQoL, is associated with a generally worse biopsychosocial profile. Further research is needed into the complex and multidimensional causal pathways explored in this study, so as to increase our understanding of the heterogeneous care needs and preferences of persons with T2DM, and translate this knowledge into tailored care and support arrangements. FAU - Elissen, Arianne M J AU - Elissen AMJ AUID- ORCID: 0000-0001-9795-8095 AD - Department of Health Services Research, Maastricht University, Maastricht, The Netherlands. AD - CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. FAU - Hertroijs, Dorijn F L AU - Hertroijs DFL AD - Department of Health Services Research, Maastricht University, Maastricht, The Netherlands. AD - CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. FAU - Schaper, Nicolaas C AU - Schaper NC AD - CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. AD - Department of Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands. AD - CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands. FAU - Bosma, Hans AU - Bosma H AD - CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. AD - Department of Social Medicine, Maastricht University, Maastricht, The Netherlands. FAU - Dagnelie, Pieter C AU - Dagnelie PC AD - CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. AD - CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands. AD - Department of Epidemiology, Maastricht University, Maastricht, The Netherlands. FAU - Henry, Ronald M AU - Henry RM AD - Department of Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands. AD - CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands. FAU - van der Kallen, Carla J AU - van der Kallen CJ AD - Department of Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands. AD - CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands. FAU - Koster, Annemarie AU - Koster A AD - CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. AD - Department of Social Medicine, Maastricht University, Maastricht, The Netherlands. FAU - Schram, Miranda T AU - Schram MT AD - Department of Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands. AD - CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands. AD - Heart and Vascular Centre, Maastricht University Medical Centre +, Maastricht, The Netherlands. FAU - Stehouwer, Coen D A AU - Stehouwer CDA AD - Department of Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands. AD - CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands. FAU - Schouten, Johannes S A G AU - Schouten JSAG AD - University Eye Clinic Maastricht, Maastricht University Medical Centre+, Maastricht, The Netherlands. FAU - Berendschot, Tos T J M AU - Berendschot TTJM AD - University Eye Clinic Maastricht, Maastricht University Medical Centre+, Maastricht, The Netherlands. FAU - Ruwaard, Dirk AU - Ruwaard D AD - Department of Health Services Research, Maastricht University, Maastricht, The Netherlands. AD - CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. LA - eng PT - Journal Article DEP - 20170727 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Blood Glucose) SB - IM MH - Blood Glucose/*metabolism MH - Diabetes Mellitus, Type 2/*blood/*psychology MH - Female MH - *Health MH - Humans MH - Male MH - Middle Aged MH - Models, Biological MH - Netherlands MH - *Quality of Life PMC - PMC5531491 COIS- Competing Interests: This study received funding from Novo Nordisk Farma B.V. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. EDAT- 2017/07/28 06:00 MHDA- 2017/10/05 06:00 PMCR- 2017/07/27 CRDT- 2017/07/28 06:00 PHST- 2017/04/20 00:00 [received] PHST- 2017/07/11 00:00 [accepted] PHST- 2017/07/28 06:00 [entrez] PHST- 2017/07/28 06:00 [pubmed] PHST- 2017/10/05 06:00 [medline] PHST- 2017/07/27 00:00 [pmc-release] AID - PONE-D-17-15377 [pii] AID - 10.1371/journal.pone.0182053 [doi] PST - epublish SO - PLoS One. 2017 Jul 27;12(7):e0182053. doi: 10.1371/journal.pone.0182053. eCollection 2017.