PMID- 28750607
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20220408
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Jul 27
TI  - Are women with type 2 diabetes mellitus more susceptible to cardiovascular 
      complications following coronary angioplasty?: a meta-analysis.
PG  - 207
LID - 10.1186/s12872-017-0645-8 [doi]
LID - 207
AB  - BACKGROUND: Scientific reports have shown Type 2 Diabetes Mellitus (T2DM) to be 
      independently associated with adverse outcomes following Percutaneous Coronary 
      Intervention (PCI). However, gender difference has also often been a 
      controversial issue following PCI. Till date, very few meta-analyses have 
      systematically compared the adverse cardiovascular outcomes in male versus female 
      patients with T2DM following PCI. Therefore, we aimed to carry out this analysis 
      in order to find out an answer to this interesting question. METHODS: Electronic 
      databases were searched for English language publications reporting adverse 
      cardiovascular outcomes in male versus female patients with diabetes mellitus 
      respectively following coronary angioplasty. The RevMan 5.3 software was used to 
      analyze selected adverse cardiovascular events whereby Odds Ratios (OR) and 95% 
      Confidence Intervals (CI) were the statistical parameters. RESULTS: A total 
      number of 19,304 patients with T2DM (12,986 male patients versus 6318 female 
      patients) were included in this analysis. At baseline, female patients were older 
      (68.7 versus 62.9 years), with a higher percentage of hypertension (75.6% versus 
      66.5%) and dyslipidemia (53.3% versus 50.0%) whereas majority of the male 
      patients were smokers (46.3% versus 14.9%). Results of this analysis showed short 
      and long-term mortality to be significantly higher in female patients with T2DM 
      (OR: 1.71, 95% CI: 1.46-2.00; P = 0.00001), and (OR: 1.20, 95% CI: 1.07-1.35; 
      P = 0.002) respectively. In addition, women were also more at risk for short and 
      long-term major adverse cardiac events (MACEs) with OR: 1.49, 95% CI: 1.07-2.07; 
      P = 0.02 and OR: 1.15, 95% CI: 1.04-1.28; P = 0.009 respectively. Subgroup 
      analysis showed this significant result to have mainly been observed in patients 
      with acute myocardial infarction compared to those with stable coronary artery 
      disease. CONCLUSIONS: Following PCI, women with T2DM were indeed more susceptible 
      to short and long-term cardiovascular complications compared to male patients 
      with the same chronic disease. Even though this result was more applicable to 
      patients with acute myocardial infarction, the fact that women were older with 
      higher co-morbidities at baseline compared to men, should also not be ignored.
FAU - Bundhun, Pravesh Kumar
AU  - Bundhun PK
AD  - Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, 530027, People's Republic of China.
FAU - Pursun, Manish
AU  - Pursun M
AD  - Guangxi Medical University, Nanning, Guangxi, 530027, People's Republic of China.
FAU - Huang, Feng
AU  - Huang F
AUID- ORCID: 0000-0002-3269-7530
AD  - Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, 530027, People's Republic of China. 
      huangfeng7925@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170727
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Aged
MH  - Cardiovascular Diseases/diagnosis/*epidemiology/mortality
MH  - Chi-Square Distribution
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology/mortality
MH  - Dyslipidemias/epidemiology
MH  - Female
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Percutaneous Coronary Intervention/*adverse effects/mortality
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Factors
MH  - Smoking/adverse effects/epidemiology
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC5530915
OTO - NOTNLM
OT  - Female sex
OT  - Gender
OT  - Major adverse cardiac events
OT  - Mortality
OT  - Percutaneous coronary intervention
OT  - Type 2 diabetes mellitus
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Ethical approval was not applicable 
      for this systematic review and meta-analysis. CONSENT FOR PUBLICATION: Not 
      applicable. COMPETING INTERESTS: The authors declare that they have no competing 
      interests. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to 
      jurisdictional claims in published maps and institutional affiliations.
EDAT- 2017/07/29 06:00
MHDA- 2018/01/09 06:00
PMCR- 2017/07/27
CRDT- 2017/07/29 06:00
PHST- 2017/05/02 00:00 [received]
PHST- 2017/07/24 00:00 [accepted]
PHST- 2017/07/29 06:00 [entrez]
PHST- 2017/07/29 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/07/27 00:00 [pmc-release]
AID - 10.1186/s12872-017-0645-8 [pii]
AID - 645 [pii]
AID - 10.1186/s12872-017-0645-8 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2017 Jul 27;17(1):207. doi: 10.1186/s12872-017-0645-8.