PMID- 28752260
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20191026
IS  - 1435-1102 (Electronic)
IS  - 1434-1816 (Print)
IS  - 1434-1816 (Linking)
VI  - 20
IP  - 6
DP  - 2017 Dec
TI  - Correlates of early pregnancy serum brain-derived neurotrophic factor in a 
      Peruvian population.
PG  - 777-785
LID - 10.1007/s00737-017-0759-0 [doi]
AB  - Knowledge about factors that influence serum brain-derived neurotrophic factor 
      (BDNF) concentrations during early pregnancy is lacking. The aim of the study is 
      to examine the correlates of early pregnancy serum BDNF concentrations. A total 
      of 982 women attending prenatal care clinics in Lima, Peru, were recruited in 
      early pregnancy. Pearson's correlation coefficient was calculated to evaluate the 
      relation between BDNF concentrations and continuous covariates. Analysis of 
      variance and generalized linear models were used to compare the unadjusted and 
      adjusted BDNF concentrations according to categorical variables. Multivariable 
      linear regression models were applied to determine the factors that influence 
      early pregnancy serum BDNF concentrations. In bivariate analysis, early pregnancy 
      serum BDNF concentrations were positively associated with maternal age (r = 0.16, 
      P < 0.001) and early pregnancy body mass index (BMI) (r = 0.17, P < 0.001), but 
      inversely correlated with gestational age at sample collection (r = -0.21, 
      P < 0.001) and C-reactive protein (CRP) concentrations (r = -0.07, P < 0.05). In 
      the multivariable linear regression model, maternal age (beta = 0.11, P = 0.001), 
      early pregnancy BMI (beta = 1.58, P < 0.001), gestational age at blood collection 
      (beta = -0.33, P < 0.001), and serum CRP concentrations (beta = -0.57, P = 0.002) were 
      significantly associated with early pregnancy serum BDNF concentrations. 
      Participants with moderate antepartum depressive symptoms (Patient Health 
      Questionnaire-9 (PHQ-9) score >/= 10) had lower serum BDNF concentrations compared 
      with participants with no/mild antepartum depressive symptoms (PHQ-9 score < 10). 
      Maternal age, early pregnancy BMI, gestational age, and the presence of moderate 
      antepartum depressive symptoms were statistically significantly associated with 
      early pregnancy serum BDNF concentrations in low-income Peruvian women. 
      Biological changes of CRP during pregnancy may affect serum BDNF concentrations.
FAU - Yang, Na
AU  - Yang N
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 
      Huntington Ave, K505F, Boston, MA, 02115, USA.
AD  - Department of Epidemiology and Biostatistics, Institute of Reproductive and Child 
      Health, Peking University, Beijing, China.
FAU - Levey, Elizabeth
AU  - Levey E
AD  - Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
FAU - Gelaye, Bizu
AU  - Gelaye B
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 
      Huntington Ave, K505F, Boston, MA, 02115, USA. bgelaye@hsph.harvard.edu.
FAU - Zhong, Qiu-Yue
AU  - Zhong QY
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 
      Huntington Ave, K505F, Boston, MA, 02115, USA.
FAU - Rondon, Marta B
AU  - Rondon MB
AD  - Department of Medicine, Cayetano Heredia Peruvian University, Lima, Peru.
FAU - Sanchez, Sixto E
AU  - Sanchez SE
AD  - Universidad de Ciencias Aplicadas, Lima, Peru.
AD  - Asociacion Civil PROESA, Lima, Peru.
FAU - Williams, Michelle A
AU  - Williams MA
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 
      Huntington Ave, K505F, Boston, MA, 02115, USA.
LA  - eng
GR  - R01 HD059835/HD/NICHD NIH HHS/United States
GR  - T37 MD001449/MD/NIMHD NIH HHS/United States
GR  - R01-HD-059835/NH/NIH HHS/United States
PT  - Journal Article
DEP - 20170727
PL  - Austria
TA  - Arch Womens Ment Health
JT  - Archives of women's mental health
JID - 9815663
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - C-Reactive Protein/*metabolism
MH  - Depression/blood/*diagnosis/epidemiology
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Maternal Age
MH  - Peru/epidemiology
MH  - Poverty
MH  - Pregnancy
MH  - Pregnancy Complications/*blood/diagnosis
MH  - Pregnant Women/psychology
MH  - Prenatal Care
MH  - Regression Analysis
MH  - Young Adult
PMC - PMC5693738
MID - NIHMS908318
OTO - NOTNLM
OT  - Antepartum depressive symptoms
OT  - Brain-derived neurotrophic factor
OT  - C-reactive protein
OT  - Early pregnancy
OT  - Peru
COIS- Conflict of interest: The authors have no competing interests to declare.
EDAT- 2017/07/29 06:00
MHDA- 2018/03/20 06:00
PMCR- 2017/12/01
CRDT- 2017/07/29 06:00
PHST- 2016/07/13 00:00 [received]
PHST- 2017/07/06 00:00 [accepted]
PHST- 2017/07/29 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/07/29 06:00 [entrez]
PHST- 2017/12/01 00:00 [pmc-release]
AID - 10.1007/s00737-017-0759-0 [pii]
AID - 10.1007/s00737-017-0759-0 [doi]
PST - ppublish
SO  - Arch Womens Ment Health. 2017 Dec;20(6):777-785. doi: 10.1007/s00737-017-0759-0. 
      Epub 2017 Jul 27.