PMID- 28752716
OWN - NLM
STAT- MEDLINE
DCOM- 20190513
LR  - 20230805
IS  - 1008-9292 (Print)
IS  - 1008-9292 (Linking)
VI  - 46
IP  - 2
DP  - 2017 Mar 25
TI  - [Progress on mechanisms for pathogensto evade NOD-like receptor and Toll-like 
      receptor signaling pathways].
PG  - 218-224
AB  - The innate immune system provides a first line of defense against invading 
      pathogens, in which the pattern recognition receptors (PRR) recognize 
      pathogen-associated molecular patterns (PAMP) and initiate the downstream 
      signaling pathways to eliminate the encountered pathogens. There are two main 
      classes of such signaling pathways: NOD-like receptor (NLR) signaling pathway and 
      Toll-like receptor (TLR) signaling pathway. The microbial pathogens under 
      selective pressure have evolved numerous mechanisms to avoid and/or manipulate 
      the NLR and TLR signal transduction for survival and replication. To evade the 
      NLR signaling pathway, pathogens interfere and/or inhibit inflammasome activation 
      in innate immune cells by producing virulence factors or reducing PAMPs 
      expression. The mechanisms for pathogens to evade TLR signaling pathway include: 
      inhibition of mitogen activated protein kinases (MAPKs) cascade reaction, 
      inhibition of NF-capital KA, CyrillicB activation, and interference of down-stream signal 
      transduction by producing Toll/interleukin-1 receptor (TIR)-containing proteins 
      which bind directly with TLRs or adaptor proteins in the signaling pathway.
FAU - Yujie, H E
AU  - Yujie HE
AD  - School of Medicine, Zhejiang University City College, Hangzhou 310015, China; 
      Department of Medical Microbiology and Parasitology, Zhejiang University School 
      of Medicine, Hangzhou 310058, China.
FAU - Jianping, Pan
AU  - Jianping P
AD  - School of Medicine, Zhejiang University City College, Hangzhou 310015, China. 
      jppan@zucc.edu.cn.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhejiang Da Xue Xue Bao Yi Xue Ban
JT  - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical 
      sciences
JID - 100927946
RN  - 0 (NLR Proteins)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - *Immunity, Innate
MH  - *NLR Proteins/immunology
MH  - Receptors, Interleukin-1/metabolism
MH  - *Signal Transduction
MH  - *Toll-Like Receptors/immunology
PMC - PMC10396992
EDAT- 2017/07/29 06:00
MHDA- 2019/05/14 06:00
PMCR- 2017/04/25
CRDT- 2017/07/29 06:00
PHST- 2017/07/29 06:00 [entrez]
PHST- 2017/07/29 06:00 [pubmed]
PHST- 2019/05/14 06:00 [medline]
PHST- 2017/04/25 00:00 [pmc-release]
AID - zjdxxbyxb-46-2-218 [pii]
AID - 10.3785/j.issn.1008-9292.2017.04.16 [doi]
PST - ppublish
SO  - Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 Mar 25;46(2):218-224. doi: 
      10.3785/j.issn.1008-9292.2017.04.16.