PMID- 28753305
OWN - NLM
STAT- MEDLINE
DCOM- 20180614
LR  - 20180614
IS  - 1520-510X (Electronic)
IS  - 0020-1669 (Linking)
VI  - 56
IP  - 16
DP  - 2017 Aug 21
TI  - Mimicking a Natural Enzyme System: Cytochrome c Oxidase-Like Activity of Cu(2)O 
      Nanoparticles by Receiving Electrons from Cytochrome c.
PG  - 9400-9403
LID - 10.1021/acs.inorgchem.7b01393 [doi]
AB  - Inorganic nanomaterials-based artificial enzymes (nanozymes) have received 
      considerable attention over the past years. However, the substrates studied for 
      nanozymes have so far been limited to small organic molecules. The catalytic 
      oxidation of biomacromolecules, such as proteins, by nanozymes has not yet been 
      reported to date. In this study, we report that cuprous oxide nanoparticles 
      (Cu(2)O NPs) possess cytochrome c oxidase (CcO)-like activity and catalyze the 
      oxidation of cytochrome c (Cyt c), converting it from the ferrous state to the 
      ferric state under atmospheric oxygen conditions. Furthermore, the CcO-like 
      activity of Cu(2)O NPs is pH- and size-dependent. The lower the solution pH and 
      the smaller the particle size, the higher the CcO-like activity. The artificial 
      Cyt c-Cu(2)O NPs system closely mimics the native Cyt c-CcO enzyme system, which 
      opens new vistas in enzyme construction and potential applications.
FAU - Chen, Ming
AU  - Chen M
AD  - Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, 
      College of Chemistry and Chemical Engineering, China West Normal University , 
      Nanchong 637002, P. R. China.
FAU - Wang, Zhonghua
AU  - Wang Z
AUID- ORCID: 0000-0002-3527-5405
AD  - Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, 
      College of Chemistry and Chemical Engineering, China West Normal University , 
      Nanchong 637002, P. R. China.
FAU - Shu, Jinxia
AU  - Shu J
AD  - Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, 
      College of Chemistry and Chemical Engineering, China West Normal University , 
      Nanchong 637002, P. R. China.
FAU - Jiang, Xiaohui
AU  - Jiang X
AUID- ORCID: 0000-0002-9820-6060
AD  - Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, 
      College of Chemistry and Chemical Engineering, China West Normal University , 
      Nanchong 637002, P. R. China.
FAU - Wang, Wei
AU  - Wang W
AD  - Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, 
      College of Chemistry and Chemical Engineering, China West Normal University , 
      Nanchong 637002, P. R. China.
FAU - Shi, Zhen-Hua
AU  - Shi ZH
AD  - School of Chemistry and Chemical Engineering, University of South China , 
      Hengyang 421001, P. R. China.
FAU - Lin, Ying-Wu
AU  - Lin YW
AD  - School of Chemistry and Chemical Engineering, University of South China , 
      Hengyang 421001, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20170728
PL  - United States
TA  - Inorg Chem
JT  - Inorganic chemistry
JID - 0366543
RN  - 789U1901C5 (Copper)
RN  - 9007-43-6 (Cytochromes c)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - S88TT14065 (Oxygen)
RN  - T8BEA5064F (cuprous oxide)
SB  - IM
MH  - Biomimetic Materials/*chemistry
MH  - Catalysis
MH  - Copper/*chemistry
MH  - Cytochromes c/*chemistry
MH  - Electron Transport Complex IV/*chemistry
MH  - Hydrogen-Ion Concentration
MH  - Iron/chemistry
MH  - Nanoparticles/*chemistry
MH  - Oxidation-Reduction
MH  - Oxygen/chemistry
MH  - Particle Size
MH  - Photoelectron Spectroscopy
EDAT- 2017/07/29 06:00
MHDA- 2018/06/15 06:00
CRDT- 2017/07/29 06:00
PHST- 2017/07/29 06:00 [pubmed]
PHST- 2018/06/15 06:00 [medline]
PHST- 2017/07/29 06:00 [entrez]
AID - 10.1021/acs.inorgchem.7b01393 [doi]
PST - ppublish
SO  - Inorg Chem. 2017 Aug 21;56(16):9400-9403. doi: 10.1021/acs.inorgchem.7b01393. 
      Epub 2017 Jul 28.