PMID- 28753611
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 7
DP  - 2017
TI  - The impact of the quality of care and other factors on progression of chronic 
      kidney disease in Thai patients with Type 2 Diabetes Mellitus: A nationwide 
      cohort study.
PG  - e0180977
LID - 10.1371/journal.pone.0180977 [doi]
LID - e0180977
AB  - OBJECTIVE: The present study investigates the impact of quality of care (QoC) and 
      other factors on chronic kidney disease (CKD) stage progression among Type 2 
      Diabetes Mellitus (T2DM) patients. METHODS: This study employed a retrospective 
      cohort from a nationwide Diabetes and Hypertension study involving 595 Thai 
      hospitals. T2DM patients who were observed at least 2 times in the 3 years 
      follow-up (between 2011-2013) were included in our study. Ordinal logistic mixed 
      effect regression modeling was used to investigate the association between the 
      QoC and other factors with CKD stage progression. RESULTS: After adjusting for 
      covariates, we found that the achievement of the HbA1c clinical targets (</=7%) was 
      the only QoC indicator protective against the CKD stage progression (adjusted OR 
      = 0.76; 95%CI = 0.59-0.98; p<0.05). In terms of other covariates, age, 
      occupation, type of health insurance, region of residence, HDL-C, triglyceride, 
      hypertension and insulin sensitizer were also strongly associated with CKD stage 
      progression. CONCLUSIONS: This cohort study demonstrates the achievement of the 
      HbA1c clinical target (</=7%) is the only QoC indicator protective against 
      progression of CKD stage. Neither of the other clinical targets (BP and LDL-C) 
      nor any process of care targets could be shown to be associated with CKD stage 
      progression. Therefore, close monitoring of blood sugar control is important to 
      slow CKD progression, but long-term prospective cohorts are needed to gain better 
      insights into the impact of QoC indicators on CKD progression.
FAU - Sonthon, Paithoon
AU  - Sonthon P
AD  - Doctor of Public Health Program, Faculty of Public Health, Khon Kaen University, 
      Khon Kaen, Thailand.
AD  - Phetchabun Provincial Public Health Office, Ministry of Public Health, 
      Phetchabun, Thailand.
FAU - Promthet, Supannee
AU  - Promthet S
AD  - Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.
FAU - Changsirikulchai, Siribha
AU  - Changsirikulchai S
AD  - Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.
FAU - Rangsin, Ram
AU  - Rangsin R
AD  - Department of Military and Community Medicine, Phramongkutklao College of 
      Medicine, Bangkok, Thailand.
FAU - Thinkhamrop, Bandit
AU  - Thinkhamrop B
AD  - Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.
FAU - Rattanamongkolgul, Suthee
AU  - Rattanamongkolgul S
AD  - Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.
FAU - Hurst, Cameron P
AU  - Hurst CP
AUID- ORCID: 0000-0002-4577-8962
AD  - Center of Excellence in Biostatistics, Faculty of Medicine, Chulalongkorn 
      University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20170728
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/metabolism/*pathology
MH  - Disease Progression
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Health Care
MH  - Renal Insufficiency, Chronic/metabolism/*pathology
MH  - Retrospective Studies
MH  - Thailand
PMC - PMC5533425
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/07/29 06:00
MHDA- 2017/10/03 06:00
PMCR- 2017/07/28
CRDT- 2017/07/29 06:00
PHST- 2017/04/26 00:00 [received]
PHST- 2017/06/24 00:00 [accepted]
PHST- 2017/07/29 06:00 [entrez]
PHST- 2017/07/29 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
PHST- 2017/07/28 00:00 [pmc-release]
AID - PONE-D-17-16139 [pii]
AID - 10.1371/journal.pone.0180977 [doi]
PST - epublish
SO  - PLoS One. 2017 Jul 28;12(7):e0180977. doi: 10.1371/journal.pone.0180977. 
      eCollection 2017.